Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 4483276..4483994 Replicon chromosome
Accession NZ_CP011662
Organism Enterobacter hormaechei strain CAV1176

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AB284_RS23010 Protein ID WP_047715719.1
Coordinates 4483276..4483596 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag AB284_RS23015 Protein ID WP_047715718.1
Coordinates 4483629..4483994 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB284_RS22990 4478465..4479604 + 1140 WP_032620851.1 AAA family ATPase -
AB284_RS22995 4479601..4480662 + 1062 WP_080288371.1 DUF4435 domain-containing protein -
AB284_RS23000 4480698..4481960 - 1263 WP_032620849.1 integrase arm-type DNA-binding domain-containing protein -
AB284_RS23005 4482330..4483163 - 834 WP_047715720.1 DUF4942 domain-containing protein -
AB284_RS23010 4483276..4483596 - 321 WP_047715719.1 TA system toxin CbtA family protein Toxin
AB284_RS23015 4483629..4483994 - 366 WP_047715718.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AB284_RS23020 4484026..4484247 - 222 WP_047715716.1 DUF987 family protein -
AB284_RS23025 4484256..4484726 - 471 WP_047715715.1 DNA repair protein RadC -
AB284_RS23030 4484797..4485615 - 819 WP_047715712.1 DUF945 domain-containing protein -
AB284_RS23035 4485715..4486392 - 678 WP_047715710.1 hypothetical protein -
AB284_RS23040 4486680..4487573 - 894 WP_047715709.1 50S ribosome-binding GTPase -
AB284_RS23045 4488064..4488696 + 633 WP_028016395.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage fosA - 4466368..4510892 44524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12128.89 Da        Isoelectric Point: 5.9559

>T54821 WP_047715719.1 NZ_CP011662:c4483596-4483276 [Enterobacter hormaechei]
MHISTIPATVLVASRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDSAIQEHIEAGITLADAVNFLVERYELIRTDRKGF
TWQEQTPFLTAIDILRARRATGLMNI

Download         Length: 321 bp

>T54821 NZ_CP011662:c4483596-4483276 [Enterobacter hormaechei]
ATGCATATTTCAACTATACCGGCCACGGTACTGGTTGCGTCACGCCTGTCGCCCGTACAGGTCTGGCAACAACTGTTAAC
CTATCTGCTTGAGCATCATTACGGCCTTACGCTCAACGACACACCATTCCATGATGATTCAGCCATCCAAGAACATATCG
AAGCAGGAATAACACTGGCTGATGCGGTGAATTTTCTGGTTGAACGCTATGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAAGAGCAGACACCATTTCTGACCGCTATCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATGAATATATA
A

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13415.12 Da        Isoelectric Point: 5.5286

>AT54821 WP_047715718.1 NZ_CP011662:c4483994-4483629 [Enterobacter hormaechei]
MQSTTLYGSSAENASCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDDEALRLDLAFPLIMEQLERMLTTGE
LDPRSQHCATLHHNGLVCEADTLGSHGYVYIAIYPQSAVTR

Download         Length: 366 bp

>AT54821 NZ_CP011662:c4483994-4483629 [Enterobacter hormaechei]
ATGCAATCGACCACCTTATACGGCTCATCAGCGGAGAACGCATCCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAAGAAGGCAACCGTCTCTACTTTCTGGCTGATCGGGCTGGTTTTAATGGCTCATTCA
GTGACGATGAAGCATTGCGTCTGGACCTGGCGTTTCCACTGATAATGGAACAGCTGGAGCGGATGCTTACAACTGGAGAG
CTCGATCCCCGCAGCCAGCATTGCGCCACGCTGCATCACAACGGACTGGTCTGTGAAGCTGACACTCTCGGCTCTCATGG
TTACGTTTACATCGCTATTTATCCCCAGTCAGCCGTAACTAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References