Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3949490..3950110 Replicon chromosome
Accession NZ_CP011662
Organism Enterobacter hormaechei strain CAV1176

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag AB284_RS20430 Protein ID WP_015571250.1
Coordinates 3949892..3950110 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag AB284_RS20425 Protein ID WP_006809850.1
Coordinates 3949490..3949864 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB284_RS20415 3944617..3945810 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AB284_RS20420 3945833..3948979 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
AB284_RS20425 3949490..3949864 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
AB284_RS20430 3949892..3950110 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
AB284_RS20435 3950319..3950870 + 552 WP_023303203.1 maltose O-acetyltransferase -
AB284_RS20440 3950987..3951454 + 468 WP_017383209.1 membrane protein -
AB284_RS20445 3951426..3952886 - 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
AB284_RS20450 3952988..3953698 + 711 WP_023303201.1 GNAT family N-acetyltransferase -
AB284_RS20455 3953695..3953835 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AB284_RS20460 3953838..3954098 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T54820 WP_015571250.1 NZ_CP011662:3949892-3950110 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T54820 NZ_CP011662:3949892-3950110 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT54820 WP_006809850.1 NZ_CP011662:3949490-3949864 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT54820 NZ_CP011662:3949490-3949864 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References