Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2266568..2267173 Replicon chromosome
Accession NZ_CP011662
Organism Enterobacter hormaechei strain CAV1176

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag AB284_RS12225 Protein ID WP_012906750.1
Coordinates 2266994..2267173 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag AB284_RS12220 Protein ID WP_032619507.1
Coordinates 2266568..2266972 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB284_RS12200 2262071..2262622 + 552 WP_032619504.1 phage tail protein I -
AB284_RS12205 2262625..2264802 + 2178 WP_050019395.1 phage tail protein -
AB284_RS12210 2264802..2265380 + 579 WP_032619505.1 tail fiber assembly protein -
AB284_RS12215 2265457..2266527 + 1071 WP_032619506.1 glycosyltransferase family 9 protein -
AB284_RS12220 2266568..2266972 - 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AB284_RS12225 2266994..2267173 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
AB284_RS12230 2267457..2268731 + 1275 WP_032619509.1 ATP-binding protein -
AB284_RS12235 2268728..2269261 + 534 WP_032619510.1 glycosyltransferase family 2 protein -
AB284_RS12240 2270163..2270918 + 756 Protein_2118 DUF4225 domain-containing protein -
AB284_RS12245 2270921..2271244 + 324 WP_017384434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 2217808..2273546 55738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T54812 WP_012906750.1 NZ_CP011662:c2267173-2266994 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T54812 NZ_CP011662:c2267173-2266994 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTTAGAGTGAAAGGCAGTCATCACCAGTT
TAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATTA
AAAAACAGGCGGGGCTCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT54812 WP_032619507.1 NZ_CP011662:c2266972-2266568 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT54812 NZ_CP011662:c2266972-2266568 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGAAGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCCGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAGTACGCCGGTGCGGTATGGGCCCTAGTTGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTACCCTCATTACTGATCCGACGTATTGATCA
GTTTGTGGCCGCGCATCCTGAATATGGAAGCCGTTCGGGCTTCCTTTCTCGCGTCGCTGCTGACAAGGTTATTAATCAAC
GATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References