Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1319850..1320507 Replicon chromosome
Accession NZ_CP011662
Organism Enterobacter hormaechei strain CAV1176

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag AB284_RS07615 Protein ID WP_017382887.1
Coordinates 1320097..1320507 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AB284_RS07610 Protein ID WP_003863437.1
Coordinates 1319850..1320116 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB284_RS07590 1315256..1316689 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
AB284_RS07595 1316806..1317537 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
AB284_RS07600 1317804..1318463 + 660 WP_003863433.1 hemolysin III family protein -
AB284_RS07605 1318575..1319555 - 981 WP_032619082.1 tRNA-modifying protein YgfZ -
AB284_RS07610 1319850..1320116 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AB284_RS07615 1320097..1320507 + 411 WP_017382887.1 protein YgfX Toxin
AB284_RS07620 1320509..1321030 - 522 WP_015571793.1 flavodoxin FldB -
AB284_RS07625 1321132..1322028 + 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
AB284_RS07630 1322057..1322770 + 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AB284_RS07635 1322776..1324509 + 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T54809 WP_017382887.1 NZ_CP011662:1320097-1320507 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T54809 NZ_CP011662:1320097-1320507 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT54809 WP_003863437.1 NZ_CP011662:1319850-1320116 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT54809 NZ_CP011662:1319850-1320116 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References