Detailed information of TA system TA054806

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 159982..160701
• Replicon: chromosome
• Accession: NZ_CP011662
• Organism: Enterobacter hormaechei strain CAV1176

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A144XIR2
• Locus tag: AB284_RS01810
• Protein ID: WP_023305176.1
• Coordinates: 160381..160701 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AB284_RS01805
• Protein ID: WP_032620726.1
• Coordinates: 159982..160347 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB284_RS01775	156280..156714	+	435	WP_044488933.1	hypothetical protein	-
AB284_RS01780	156827..157666	+	840	WP_050595703.1	hypothetical protein	-
AB284_RS01785	157725..157916	+	192	WP_023305181.1	hypothetical protein	-
AB284_RS01790	158359..159180	+	822	WP_032620720.1	DUF945 domain-containing protein	-
AB284_RS01795	159250..159720	+	471	WP_032620722.1	DNA repair protein RadC	-
AB284_RS01800	159729..159950	+	222	WP_032620724.1	DUF987 domain-containing protein	-
AB284_RS01805	159982..160347	+	366	WP_032620726.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AB284_RS01810	160381..160701	+	321	WP_023305176.1	TA system toxin CbtA family protein	Toxin
AB284_RS01815	160904..161485	+	582	WP_017383635.1	hypothetical protein	-
AB284_RS01820	161487..161678	-	192	WP_032620729.1	toxin-antitoxin system HicB family antitoxin	-
AB284_RS01825	161815..162156	+	342	WP_032620730.1	SymE family type I addiction module toxin	-
AB284_RS01830	162215..163243	+	1029	WP_071842900.1	virulence RhuM family protein	-
AB284_RS01835	163507..163992	+	486	WP_017383637.1	type VI secretion system tube protein Hcp	-
AB284_RS01840	164002..164367	+	366	WP_023302859.1	DUF2778 domain-containing protein	-
AB284_RS01845	164430..164951	+	522	WP_017383638.1	hypothetical protein	-
AB284_RS01850	164984..165427	-	444	WP_017383639.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	135981..169306	33325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12190.77 Da
• Isoelectric Point: 5.9559

>T54806 WP_023305176.1 NZ_CP011662:160381-160701 [Enterobacter hormaechei]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS

Nucleotide

• Length: 321 bp

>T54806 NZ_CP011662:160381-160701 [Enterobacter hormaechei]
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13574.29 Da
• Isoelectric Point: 6.4673

>AT54806 WP_032620726.1 NZ_CP011662:159982-160347 [Enterobacter hormaechei]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Nucleotide

• Length: 366 bp

>AT54806 NZ_CP011662:159982-160347 [Enterobacter hormaechei]
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA

Structures

Toxin

• AlphaFold DB: A0A144XIR2