Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3181809..3182440 Replicon chromosome
Accession NZ_CP011657
Organism Citrobacter freundii strain CAV1741

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag AB183_RS17125 Protein ID WP_003837806.1
Coordinates 3181809..3182084 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag AB183_RS17130 Protein ID WP_003837808.1
Coordinates 3182081..3182440 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB183_RS17115 3177860..3180607 + 2748 WP_044701369.1 ribosome-associated ATPase/putative transporter RbbA -
AB183_RS17120 3180607..3181731 + 1125 WP_003837801.1 ABC transporter permease -
AB183_RS17125 3181809..3182084 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
AB183_RS17130 3182081..3182440 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AB183_RS17135 3182551..3182952 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
AB183_RS17140 3183002..3183580 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
AB183_RS17145 3183643..3184692 - 1050 WP_003023393.1 AI-2E family transporter -
AB183_RS17150 3184826..3186043 + 1218 WP_003846164.1 MFS transporter -
AB183_RS17155 3186047..3186604 - 558 WP_003837816.1 DcrB family lipoprotein -
AB183_RS17160 3186677..3187342 - 666 WP_044701371.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T54802 WP_003837806.1 NZ_CP011657:3181809-3182084 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T54802 NZ_CP011657:3181809-3182084 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT54802 WP_003837808.1 NZ_CP011657:3182081-3182440 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT54802 NZ_CP011657:3182081-3182440 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTAATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References