Detailed information of TA system TA054798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2278060..2278576
• Replicon: chromosome
• Accession: NZ_CP011657
• Organism: Citrobacter freundii strain CAV1741

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AB183_RS12820
• Protein ID: WP_044699148.1
• Coordinates: 2278060..2278344 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0J1MV10
• Locus tag: AB183_RS12825
• Protein ID: WP_003839576.1
• Coordinates: 2278334..2278576 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB183_RS12805	2274385..2274969	+	585	WP_003839584.1	fructose PTS transporter subunit IIA	-
AB183_RS12810	2275347..2277485	+	2139	WP_003025782.1	anaerobic ribonucleoside-triphosphate reductase	-
AB183_RS12815	2277592..2278056	+	465	WP_032937736.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
AB183_RS12820	2278060..2278344	-	285	WP_044699148.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AB183_RS12825	2278334..2278576	-	243	WP_003839576.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AB183_RS12830	2278654..2280567	-	1914	WP_003839574.1	BglG family transcription antiterminator	-
AB183_RS12835	2280589..2281329	-	741	WP_044699149.1	KDGP aldolase family protein	-
AB183_RS12840	2281326..2282444	-	1119	WP_044699152.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
AB183_RS12845	2282428..2283561	-	1134	WP_016149471.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10865.69 Da
• Isoelectric Point: 10.1988

>T54798 WP_044699148.1 NZ_CP011657:c2278344-2278060 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Nucleotide

• Length: 285 bp

>T54798 NZ_CP011657:c2278344-2278060 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGACAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT54798 WP_003839576.1 NZ_CP011657:c2278576-2278334 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT54798 NZ_CP011657:c2278576-2278334 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0J1MV10