Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4499586..4500305 | Replicon | chromosome |
| Accession | NZ_CP011650 | ||
| Organism | Enterobacter hormaechei strain CAV1669 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A144XIR2 |
| Locus tag | AB285_RS22110 | Protein ID | WP_023305176.1 |
| Coordinates | 4499586..4499906 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | AB285_RS22115 | Protein ID | WP_032620726.1 |
| Coordinates | 4499940..4500305 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AB285_RS22075 | 4494860..4495303 | + | 444 | WP_017383639.1 | GNAT family N-acetyltransferase | - |
| AB285_RS22080 | 4495336..4495857 | - | 522 | WP_017383638.1 | hypothetical protein | - |
| AB285_RS24750 | 4495920..4496285 | - | 366 | WP_023302859.1 | DUF2778 domain-containing protein | - |
| AB285_RS22085 | 4496295..4496780 | - | 486 | WP_017383637.1 | type VI secretion system tube protein Hcp | - |
| AB285_RS22090 | 4497044..4498072 | - | 1029 | WP_071842900.1 | virulence RhuM family protein | - |
| AB285_RS22095 | 4498131..4498472 | - | 342 | WP_032620730.1 | SymE family type I addiction module toxin | - |
| AB285_RS22100 | 4498609..4498800 | + | 192 | WP_032620729.1 | toxin-antitoxin system HicB family antitoxin | - |
| AB285_RS22105 | 4498802..4499383 | - | 582 | WP_017383635.1 | hypothetical protein | - |
| AB285_RS22110 | 4499586..4499906 | - | 321 | WP_023305176.1 | TA system toxin CbtA family protein | Toxin |
| AB285_RS22115 | 4499940..4500305 | - | 366 | WP_032620726.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AB285_RS22120 | 4500337..4500558 | - | 222 | WP_032620724.1 | DUF987 domain-containing protein | - |
| AB285_RS22125 | 4500567..4501037 | - | 471 | WP_032620722.1 | DNA repair protein RadC | - |
| AB285_RS22130 | 4501107..4501928 | - | 822 | WP_032620720.1 | DUF945 domain-containing protein | - |
| AB285_RS24755 | 4502371..4502562 | - | 192 | WP_023305181.1 | hypothetical protein | - |
| AB285_RS23890 | 4502621..4503460 | - | 840 | WP_050595703.1 | hypothetical protein | - |
| AB285_RS22140 | 4503573..4504007 | - | 435 | WP_044488933.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4492418..4525548 | 33130 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12190.77 Da Isoelectric Point: 5.9559
>T54785 WP_023305176.1 NZ_CP011650:c4499906-4499586 [Enterobacter hormaechei]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS
Download Length: 321 bp
>T54785 NZ_CP011650:c4499906-4499586 [Enterobacter hormaechei]
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
Antitoxin
Download Length: 122 a.a. Molecular weight: 13574.29 Da Isoelectric Point: 6.4673
>AT54785 WP_032620726.1 NZ_CP011650:c4500305-4499940 [Enterobacter hormaechei]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR
Download Length: 366 bp
>AT54785 NZ_CP011650:c4500305-4499940 [Enterobacter hormaechei]
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|