Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2392286..2392891 Replicon chromosome
Accession NZ_CP011650
Organism Enterobacter hormaechei strain CAV1669

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag AB285_RS12020 Protein ID WP_012906750.1
Coordinates 2392286..2392465 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag AB285_RS12025 Protein ID WP_032619507.1
Coordinates 2392487..2392891 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB285_RS12000 2388215..2388538 - 324 WP_017384434.1 hypothetical protein -
AB285_RS12005 2388541..2389296 - 756 Protein_2240 DUF4225 domain-containing protein -
AB285_RS12010 2390198..2390731 - 534 WP_032619510.1 glycosyltransferase family 2 protein -
AB285_RS12015 2390728..2392002 - 1275 WP_032619509.1 ATP-binding protein -
AB285_RS12020 2392286..2392465 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
AB285_RS12025 2392487..2392891 + 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AB285_RS12030 2392932..2394002 - 1071 WP_032619506.1 glycosyltransferase family 9 protein -
AB285_RS12035 2394079..2394657 - 579 WP_032619505.1 tail fiber assembly protein -
AB285_RS23870 2394657..2396834 - 2178 WP_050019395.1 phage tail protein -
AB285_RS12050 2396837..2397388 - 552 WP_032619504.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 2385913..2441651 55738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T54779 WP_012906750.1 NZ_CP011650:2392286-2392465 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T54779 NZ_CP011650:2392286-2392465 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTTAGAGTGAAAGGCAGTCATCACCAGTT
TAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATTA
AAAAACAGGCGGGGCTCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT54779 WP_032619507.1 NZ_CP011650:2392487-2392891 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT54779 NZ_CP011650:2392487-2392891 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGAAGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCCGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAGTACGCCGGTGCGGTATGGGCCCTAGTTGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTACCCTCATTACTGATCCGACGTATTGATCA
GTTTGTGGCCGCGCATCCTGAATATGGAAGCCGTTCGGGCTTCCTTTCTCGCGTCGCTGCTGACAAGGTTATTAATCAAC
GATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References