54759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2419945..2420564 Replicon chromosome
Accession NZ_CP011647
Organism Klebsiella pneumoniae strain CAV1596

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AB187_RS13425 Protein ID WP_002892050.1
Coordinates 2419945..2420163 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag AB187_RS13430 Protein ID WP_002892066.1
Coordinates 2420190..2420564 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB187_RS13390 2415992..2416255 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
AB187_RS13395 2416255..2416395 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
AB187_RS13400 2416392..2417090 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
AB187_RS13405 2417191..2418642 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
AB187_RS13410 2418617..2419087 - 471 WP_002892026.1 YlaC family protein -
AB187_RS30935 2419108..2419248 + 141 WP_004147370.1 hypothetical protein -
AB187_RS13420 2419220..2419786 - 567 WP_002892030.1 maltose O-acetyltransferase -
AB187_RS13425 2419945..2420163 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AB187_RS13430 2420190..2420564 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
AB187_RS13435 2421050..2424196 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
AB187_RS13440 2424219..2425412 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T54759 WP_002892050.1 NZ_CP011647:c2420163-2419945 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T54759 NZ_CP011647:c2420163-2419945 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT54759 WP_002892066.1 NZ_CP011647:c2420564-2420190 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT54759 NZ_CP011647:c2420564-2420190 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References