Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3524281..3524950 Replicon chromosome
Accession NZ_CP011642
Organism Serratia marcescens strain CAV1492

Toxin (Protein)


Gene name cptA Uniprot ID A0A5P6GZ53
Locus tag AB188_RS18345 Protein ID WP_047729923.1
Coordinates 3524528..3524950 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag AB188_RS18340 Protein ID WP_019455657.1
Coordinates 3524281..3524547 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB188_RS18315 3519856..3520782 + 927 WP_047729921.1 ribokinase -
AB188_RS18320 3520815..3521423 - 609 WP_025304127.1 HD domain-containing protein -
AB188_RS18325 3521607..3522281 + 675 WP_038871224.1 hemolysin III family protein -
AB188_RS18330 3522432..3522929 + 498 WP_038871226.1 DUF2165 domain-containing protein -
AB188_RS18335 3522968..3523960 - 993 WP_047729922.1 tRNA-modifying protein YgfZ -
AB188_RS18340 3524281..3524547 + 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
AB188_RS18345 3524528..3524950 + 423 WP_047729923.1 protein YgfX Toxin
AB188_RS18350 3524950..3525645 + 696 WP_047729924.1 two-component system response regulator CreB -
AB188_RS18355 3525642..3527060 + 1419 WP_047729925.1 two-component system sensor histidine kinase CreC -
AB188_RS18360 3527141..3528505 + 1365 WP_047729926.1 cell envelope integrity protein CreD -
AB188_RS18365 3528542..3529060 - 519 WP_038871234.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16500.57 Da        Isoelectric Point: 10.8114

>T54742 WP_047729923.1 NZ_CP011642:3524528-3524950 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPVGDGEEA

Download         Length: 423 bp

>T54742 NZ_CP011642:3524528-3524950 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGTTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
TGGGTGACGGCGAGGAGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT54742 WP_019455657.1 NZ_CP011642:3524281-3524547 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT54742 NZ_CP011642:3524281-3524547 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GZ53

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References