Detailed information of TA system TA054739

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 2469790..2470556
• Replicon: chromosome
• Accession: NZ_CP011642
• Organism: Serratia marcescens strain CAV1492

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A1Q4NZ32
• Locus tag: AB188_RS13505
• Protein ID: WP_047729506.1
• Coordinates: 2469790..2470158 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: AB188_RS28365
• Protein ID: WP_071845327.1
• Coordinates: 2470221..2470556 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB188_RS13480	2464889..2466055	-	1167	WP_047729497.1	MFS transporter	-
AB188_RS13485	2466230..2466985	-	756	WP_047729499.1	nucleotidyltransferase domain-containing protein	-
AB188_RS13490	2466972..2467484	-	513	WP_047729501.1	DUF962 domain-containing protein	-
AB188_RS13495	2467691..2468734	-	1044	WP_047729502.1	virulence RhuM family protein	-
AB188_RS13500	2468824..2469657	-	834	WP_047729504.1	DUF4942 domain-containing protein	-
AB188_RS13505	2469790..2470158	-	369	WP_047729506.1	TA system toxin CbtA family protein	Toxin
AB188_RS28365	2470221..2470556	-	336	WP_071845327.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AB188_RS13515	2470568..2471047	-	480	WP_047729511.1	DNA repair protein RadC	-
AB188_RS13520	2471229..2471849	-	621	WP_047730810.1	hypothetical protein	-
AB188_RS13525	2471877..2472431	-	555	WP_047729513.1	hypothetical protein	-
AB188_RS13530	2472679..2473434	-	756	WP_047730811.1	50S ribosome-binding GTPase	-
AB188_RS13535	2473643..2474449	-	807	WP_047729515.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2468824..2490798	21974

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (8-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13731.73 Da
• Isoelectric Point: 7.2753

>T54739 WP_047729506.1 NZ_CP011642:c2470158-2469790 [Serratia marcescens]
MQTLPVTPKRAAYGCPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDTVIHEHIDAGISLADALNFTVEKFGLVRIDRRGF
SYREQSPFITAIDILRARRATGLMTRLGYQTITSVIRGEKQA

Nucleotide

• Length: 369 bp

>T54739 NZ_CP011642:c2470158-2469790 [Serratia marcescens]
ATGCAGACCTTACCTGTCACCCCGAAACGGGCGGCCTACGGTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATTTGCTGGAGCAGCATTACGGCTTGGCGCTTAACGATACCGAGTTCAGTGATGACACCGTGATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGTTGAATTTCACGGTAGAAAAGTTTGGCCTGGTTCGCATCGATCGCCGGGGGTTT
TCCTATAGGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGCGCCCGTCGGGCCACCGGCCTAATGACCCGGCT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGAGAAAAGCAAGCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12341.01 Da
• Isoelectric Point: 4.9764

>AT54739 WP_071845327.1 NZ_CP011642:c2470556-2470221 [Serratia marcescens]
MPSIIAPVWGLKRNVTPQFGARLVQEGGRLHFLADRADISGTFSDEQLRDVDNAFPQFINHLELMLLSGELNPRYQHCVT
LYCNGLTCEADSLGSQGYVYLAIYPTPQPTA

Nucleotide

• Length: 336 bp

>AT54739 NZ_CP011642:c2470556-2470221 [Serratia marcescens]
ATGCCATCAATCATTGCCCCTGTCTGGGGACTTAAACGTAACGTCACTCCGCAGTTTGGCGCCCGCCTGGTACAGGAAGG
CGGGCGACTGCACTTCCTGGCTGACCGTGCCGATATCAGCGGTACCTTCAGCGACGAGCAGCTGCGTGACGTAGATAACG
CCTTCCCGCAGTTCATCAACCACCTGGAACTGATGCTGCTTTCTGGTGAGCTCAATCCCCGTTATCAGCACTGTGTCACG
CTGTATTGCAATGGCTTGACCTGCGAAGCCGACAGTCTGGGATCACAGGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAACCAACTGCATAA

Structures

Toxin

• AlphaFold DB: A0A1Q4NZ32