Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5522479..5523117 Replicon chromosome
Accession NZ_CP011618
Organism Klebsiella oxytoca strain CAV1335

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AB181_RS28360 Protein ID WP_047043763.1
Coordinates 5522935..5523117 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AB181_RS28355 Protein ID WP_047720836.1
Coordinates 5522479..5522910 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB181_RS28335 5517595..5517852 + 258 WP_004122994.1 hypothetical protein -
AB181_RS28340 5517852..5518736 + 885 WP_047720833.1 phage N-6-adenine-methyltransferase -
AB181_RS28345 5518729..5520576 + 1848 WP_047720834.1 DNA cytosine methyltransferase -
AB181_RS28350 5520573..5521634 + 1062 WP_047720835.1 DUF968 domain-containing protein -
AB181_RS33120 5521647..5522249 + 603 WP_071845044.1 hypothetical protein -
AB181_RS28355 5522479..5522910 - 432 WP_047720836.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AB181_RS28360 5522935..5523117 - 183 WP_047043763.1 type II toxin-antitoxin system HicA family toxin Toxin
AB181_RS28365 5523359..5523688 + 330 WP_139153342.1 phage holin, lambda family -
AB181_RS28370 5523675..5524094 + 420 WP_047720838.1 structural protein -
AB181_RS28375 5524097..5524564 + 468 WP_047720839.1 lysis protein -
AB181_RS28380 5524795..5525025 + 231 WP_047720840.1 hypothetical protein -
AB181_RS34215 5525809..5526066 - 258 WP_139153332.1 hypothetical protein -
AB181_RS28385 5526523..5526708 + 186 WP_047720841.1 hypothetical protein -
AB181_RS28390 5526799..5527131 + 333 WP_047720842.1 hypothetical protein -
AB181_RS28395 5527131..5527550 + 420 WP_047720843.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5493053..5569551 76498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-137)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6508.74 Da        Isoelectric Point: 10.8930

>T54694 WP_047043763.1 NZ_CP011618:c5523117-5522935 [Klebsiella oxytoca]
MKSTDLIKELIAAGCELKRQGKGSHQIWWSPITGKTFPVPHPKGNLPIGTIKSIKKTAGI

Download         Length: 183 bp

>T54694 NZ_CP011618:c5523117-5522935 [Klebsiella oxytoca]
ATGAAATCGACTGACCTGATAAAGGAATTGATAGCCGCCGGATGTGAACTCAAAAGGCAAGGGAAAGGCAGTCACCAGAT
ATGGTGGTCGCCGATAACGGGAAAAACATTCCCGGTTCCACACCCTAAGGGCAACCTACCGATCGGCACCATCAAATCCA
TCAAGAAAACGGCGGGGATCTAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16029.07 Da        Isoelectric Point: 4.2696

>AT54694 WP_047720836.1 NZ_CP011618:c5522910-5522479 [Klebsiella oxytoca]
MFFSVGVETPKDENTAYGMIVPAFSAYEMGCFSAADTQDQIAPMVKEAILLSVECLVEDAGRSVDEIKDAGYMVYAANPE
YKDFDSWFMVEVDLSEFEGKPQRINISLPDTLIKRIDNAVKGNASYRDRSHFLAEAARHELKQ

Download         Length: 432 bp

>AT54694 NZ_CP011618:c5522910-5522479 [Klebsiella oxytoca]
ATGTTCTTTTCAGTGGGCGTTGAGACGCCAAAAGATGAAAACACCGCCTACGGTATGATTGTTCCTGCGTTTTCAGCTTA
TGAGATGGGTTGCTTCTCCGCCGCTGATACACAGGACCAGATCGCGCCAATGGTTAAAGAAGCCATTCTCTTAAGCGTTG
AGTGCCTGGTCGAAGATGCAGGGCGCAGCGTCGATGAAATCAAAGACGCCGGCTATATGGTGTATGCAGCTAACCCAGAA
TATAAGGACTTTGACAGCTGGTTCATGGTTGAAGTTGATTTGTCTGAGTTCGAAGGCAAGCCACAACGTATCAATATTTC
ACTGCCTGATACGCTGATTAAGCGCATCGATAATGCTGTAAAGGGTAACGCCAGCTATCGAGACAGAAGCCATTTTCTGG
CTGAAGCTGCCCGACACGAACTGAAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References