Detailed information of TA system TA054693

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5040368..5041140
• Replicon: chromosome
• Accession: NZ_CP011618
• Organism: Klebsiella oxytoca strain CAV1335

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AB181_RS26095
• Protein ID: WP_165569689.1
• Coordinates: 5040368..5040736 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AB181_RS26100
• Protein ID: WP_047720742.1
• Coordinates: 5040781..5041140 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB181_RS26075	5035922..5037283	-	1362	WP_047720739.1	hypothetical protein	-
AB181_RS26080	5037756..5038076	-	321	WP_047720740.1	hypothetical protein	-
AB181_RS26085	5038840..5039829	+	990	WP_047720741.1	glycosyltransferase	-
AB181_RS26090	5039968..5040288	+	321	WP_047058025.1	hypothetical protein	-
AB181_RS26095	5040368..5040736	-	369	WP_165569689.1	TA system toxin CbtA family protein	Toxin
AB181_RS26100	5040781..5041140	-	360	WP_047720742.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AB181_RS26105	5041163..5041384	-	222	WP_032938028.1	DUF987 domain-containing protein	-
AB181_RS26110	5041398..5041880	-	483	WP_047720743.1	DNA repair protein RadC	-
AB181_RS26115	5042121..5042594	-	474	WP_047720744.1	antirestriction protein	-
AB181_RS26120	5042673..5043494	-	822	WP_004136895.1	DUF945 domain-containing protein	-
AB181_RS26125	5043601..5043813	-	213	WP_047720745.1	hypothetical protein	-
AB181_RS26130	5043899..5044258	-	360	WP_004136901.1	hypothetical protein	-
AB181_RS26135	5044313..5044777	-	465	WP_004136903.1	hypothetical protein	-
AB181_RS26140	5045055..5045912	-	858	WP_025107340.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5026466..5063521	37055

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-110)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13644.59 Da
• Isoelectric Point: 9.7700

>T54693 WP_165569689.1 NZ_CP011618:c5040736-5040368 [Klebsiella oxytoca]
IQSLPPQRAASSRLSSVKIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGFSV
KEQSPFIGSLDMLRDRKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 369 bp

>T54693 NZ_CP011618:c5040736-5040368 [Klebsiella oxytoca]
ATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCAAAATCTGGCAAAAATTACTGGAGTATCT
GCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAACACATTGATGCGG
GAATCTCACTGTGTGACGCTGTGAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTCAGCGTG
AAAGAGCAGTCTCCGTTTATCGGCAGCCTTGATATGCTCCGAGACCGGAAGGCTACTGGGCTGATGACCCGCAAGGGATA
TAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13394.53 Da
• Isoelectric Point: 8.1441

>AT54693 WP_047720742.1 NZ_CP011618:c5041140-5040781 [Klebsiella oxytoca]
MQKATRVINHNIAEPWWGLRRNVTPCFGARLVQEGNRLHYLADRASTTGTFNDADLRHLDQAFPLLMKQMELMLTSSELM
PRIQRCITLHAKGLICEADTLGSCGYLYIVIYPASATTA

Nucleotide

• Length: 360 bp

>AT54693 NZ_CP011618:c5041140-5040781 [Klebsiella oxytoca]
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCGCGGAACCCTGGTGGGGCCTCAGACGCAACGTCACGCCATGTTT
TGGTGCCCGGCTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCAGCACCACCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGTTACTGATGAAGCAGATGGAGCTCATGCTGACCAGCAGCGAACTCATG
CCCCGCATTCAGCGCTGCATCACGCTCCATGCAAAAGGGCTGATATGTGAGGCCGATACGCTCGGTTCCTGTGGCTATTT
GTACATCGTAATTTATCCGGCGTCTGCAACAACCGCATAA