Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4589045..4589702 Replicon chromosome
Accession NZ_CP011618
Organism Klebsiella oxytoca strain CAV1335

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag AB181_RS23955 Protein ID WP_004105559.1
Coordinates 4589292..4589702 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag AB181_RS23950 Protein ID WP_004105561.1
Coordinates 4589045..4589311 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB181_RS23925 4584225..4585658 - 1434 WP_004105576.1 6-phospho-beta-glucosidase -
AB181_RS23930 4585779..4586507 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
AB181_RS23935 4586558..4586869 + 312 WP_017145456.1 N(4)-acetylcytidine aminohydrolase -
AB181_RS23940 4587031..4587690 + 660 WP_004105569.1 hemolysin III family protein -
AB181_RS23945 4587818..4588801 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
AB181_RS23950 4589045..4589311 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
AB181_RS23955 4589292..4589702 + 411 WP_004105559.1 protein YgfX Toxin
AB181_RS23960 4589711..4590232 - 522 WP_004105557.1 flavodoxin FldB -
AB181_RS23965 4590354..4591250 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
AB181_RS23970 4591273..4591986 + 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AB181_RS23975 4591992..4593725 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T54692 WP_004105559.1 NZ_CP011618:4589292-4589702 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T54692 NZ_CP011618:4589292-4589702 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCAGACAGGGGGAAATAAAGTTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATCAATAGCGGAATGCTGCTGCGTCTGCGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT54692 WP_004105561.1 NZ_CP011618:4589045-4589311 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT54692 NZ_CP011618:4589045-4589311 [Klebsiella oxytoca]
ATGGATATTAACAATAAAGCTCGCATCCACTGGGCATGCCGCCGGGGAATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATACGCTCAGTGATGACGATAAGCGGTTGTTCATCCGCCTGCTGGAAAATGACGATCCGGACC
TGTTCAACTGGTTGATGAACCATGGCGAACCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References