Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2281103..2281757 Replicon chromosome
Accession NZ_CP011612
Organism Citrobacter freundii strain CAV1321

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag AB180_RS13875 Protein ID WP_003026936.1
Coordinates 2281103..2281510 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag AB180_RS13880 Protein ID WP_003026938.1
Coordinates 2281491..2281757 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB180_RS13855 2277051..2278784 - 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -
AB180_RS13860 2278790..2279503 - 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AB180_RS13865 2279527..2280423 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
AB180_RS13870 2280537..2281058 + 522 WP_003026933.1 flavodoxin FldB -
AB180_RS13875 2281103..2281510 - 408 WP_003026936.1 protein YgfX Toxin
AB180_RS13880 2281491..2281757 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
AB180_RS13885 2282014..2282994 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
AB180_RS13890 2283088..2283747 - 660 WP_003838267.1 hemolysin III family protein -
AB180_RS13895 2283910..2284221 - 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
AB180_RS13900 2284274..2285002 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
AB180_RS13905 2285123..2286556 + 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T54679 WP_003026936.1 NZ_CP011612:c2281510-2281103 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T54679 NZ_CP011612:c2281510-2281103 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT54679 WP_003026938.1 NZ_CP011612:c2281757-2281491 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT54679 NZ_CP011612:c2281757-2281491 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References