Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5496177..5496815 Replicon chromosome
Accession NZ_CP011597
Organism Klebsiella oxytoca strain CAV1099

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AB184_RS28070 Protein ID WP_047043763.1
Coordinates 5496633..5496815 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AB184_RS28065 Protein ID WP_047720836.1
Coordinates 5496177..5496608 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB184_RS28045 5491293..5491550 + 258 WP_004122994.1 hypothetical protein -
AB184_RS28050 5491550..5492434 + 885 WP_047720833.1 phage N-6-adenine-methyltransferase -
AB184_RS28055 5492427..5494274 + 1848 WP_047720834.1 DNA cytosine methyltransferase -
AB184_RS28060 5494271..5495332 + 1062 WP_047720835.1 DUF968 domain-containing protein -
AB184_RS32850 5495345..5495947 + 603 WP_071845044.1 hypothetical protein -
AB184_RS28065 5496177..5496608 - 432 WP_047720836.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AB184_RS28070 5496633..5496815 - 183 WP_047043763.1 type II toxin-antitoxin system HicA family toxin Toxin
AB184_RS28075 5497057..5497386 + 330 WP_139153342.1 phage holin, lambda family -
AB184_RS28080 5497373..5497792 + 420 WP_047720838.1 structural protein -
AB184_RS28085 5497795..5498262 + 468 WP_047720839.1 lysis protein -
AB184_RS28090 5498493..5498723 + 231 WP_047720840.1 hypothetical protein -
AB184_RS33880 5499507..5499764 - 258 WP_139153332.1 hypothetical protein -
AB184_RS28095 5500221..5500406 + 186 WP_047720841.1 hypothetical protein -
AB184_RS28100 5500497..5500829 + 333 WP_047720842.1 hypothetical protein -
AB184_RS28105 5500829..5501248 + 420 WP_047720843.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5482453..5548545 66092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-137)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6508.74 Da        Isoelectric Point: 10.8930

>T54658 WP_047043763.1 NZ_CP011597:c5496815-5496633 [Klebsiella oxytoca]
MKSTDLIKELIAAGCELKRQGKGSHQIWWSPITGKTFPVPHPKGNLPIGTIKSIKKTAGI

Download         Length: 183 bp

>T54658 NZ_CP011597:c5496815-5496633 [Klebsiella oxytoca]
ATGAAATCGACTGACCTGATAAAGGAATTGATAGCCGCCGGATGTGAACTCAAAAGGCAAGGGAAAGGCAGTCACCAGAT
ATGGTGGTCGCCGATAACGGGAAAAACATTCCCGGTTCCACACCCTAAGGGCAACCTACCGATCGGCACCATCAAATCCA
TCAAGAAAACGGCGGGGATCTAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16029.07 Da        Isoelectric Point: 4.2696

>AT54658 WP_047720836.1 NZ_CP011597:c5496608-5496177 [Klebsiella oxytoca]
MFFSVGVETPKDENTAYGMIVPAFSAYEMGCFSAADTQDQIAPMVKEAILLSVECLVEDAGRSVDEIKDAGYMVYAANPE
YKDFDSWFMVEVDLSEFEGKPQRINISLPDTLIKRIDNAVKGNASYRDRSHFLAEAARHELKQ

Download         Length: 432 bp

>AT54658 NZ_CP011597:c5496608-5496177 [Klebsiella oxytoca]
ATGTTCTTTTCAGTGGGCGTTGAGACGCCAAAAGATGAAAACACCGCCTACGGTATGATTGTTCCTGCGTTTTCAGCTTA
TGAGATGGGTTGCTTCTCCGCCGCTGATACACAGGACCAGATCGCGCCAATGGTTAAAGAAGCCATTCTCTTAAGCGTTG
AGTGCCTGGTCGAAGATGCAGGGCGCAGCGTCGATGAAATCAAAGACGCCGGCTATATGGTGTATGCAGCTAACCCAGAA
TATAAGGACTTTGACAGCTGGTTCATGGTTGAAGTTGATTTGTCTGAGTTCGAAGGCAAGCCACAACGTATCAATATTTC
ACTGCCTGATACGCTGATTAAGCGCATCGATAATGCTGTAAAGGGTAACGCCAGCTATCGAGACAGAAGCCATTTTCTGG
CTGAAGCTGCCCGACACGAACTGAAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References