Detailed information of TA system TA054657

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5017884..5018656
• Replicon: chromosome
• Accession: NZ_CP011597
• Organism: Klebsiella oxytoca strain CAV1099

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AB184_RS25815
• Protein ID: WP_165569689.1
• Coordinates: 5017884..5018252 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AB184_RS25820
• Protein ID: WP_047720742.1
• Coordinates: 5018297..5018656 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB184_RS25795	5013438..5014799	-	1362	WP_047720739.1	hypothetical protein	-
AB184_RS25800	5015272..5015592	-	321	WP_047720740.1	hypothetical protein	-
AB184_RS25805	5016356..5017345	+	990	WP_047720741.1	glycosyltransferase	-
AB184_RS25810	5017484..5017804	+	321	WP_047058025.1	hypothetical protein	-
AB184_RS25815	5017884..5018252	-	369	WP_165569689.1	TA system toxin CbtA family protein	Toxin
AB184_RS25820	5018297..5018656	-	360	WP_047720742.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AB184_RS25825	5018679..5018900	-	222	WP_032938028.1	DUF987 domain-containing protein	-
AB184_RS25830	5018914..5019396	-	483	WP_047720743.1	DNA repair protein RadC	-
AB184_RS25835	5019637..5020110	-	474	WP_047720744.1	antirestriction protein	-
AB184_RS25840	5020189..5021010	-	822	WP_004136895.1	DUF945 domain-containing protein	-
AB184_RS25845	5021117..5021329	-	213	WP_047720745.1	hypothetical protein	-
AB184_RS25850	5021415..5021774	-	360	WP_004136901.1	hypothetical protein	-
AB184_RS25855	5021829..5022293	-	465	WP_004136903.1	hypothetical protein	-
AB184_RS25860	5022571..5023428	-	858	WP_025107340.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5003982..5041037	37055

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-110)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13644.59 Da
• Isoelectric Point: 9.7700

>T54657 WP_165569689.1 NZ_CP011597:c5018252-5017884 [Klebsiella oxytoca]
IQSLPPQRAASSRLSSVKIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGFSV
KEQSPFIGSLDMLRDRKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 369 bp

>T54657 NZ_CP011597:c5018252-5017884 [Klebsiella oxytoca]
ATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCAAAATCTGGCAAAAATTACTGGAGTATCT
GCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAACACATTGATGCGG
GAATCTCACTGTGTGACGCTGTGAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTCAGCGTG
AAAGAGCAGTCTCCGTTTATCGGCAGCCTTGATATGCTCCGAGACCGGAAGGCTACTGGGCTGATGACCCGCAAGGGATA
TAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13394.53 Da
• Isoelectric Point: 8.1441

>AT54657 WP_047720742.1 NZ_CP011597:c5018656-5018297 [Klebsiella oxytoca]
MQKATRVINHNIAEPWWGLRRNVTPCFGARLVQEGNRLHYLADRASTTGTFNDADLRHLDQAFPLLMKQMELMLTSSELM
PRIQRCITLHAKGLICEADTLGSCGYLYIVIYPASATTA

Nucleotide

• Length: 360 bp

>AT54657 NZ_CP011597:c5018656-5018297 [Klebsiella oxytoca]
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCGCGGAACCCTGGTGGGGCCTCAGACGCAACGTCACGCCATGTTT
TGGTGCCCGGCTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCAGCACCACCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGTTACTGATGAAGCAGATGGAGCTCATGCTGACCAGCAGCGAACTCATG
CCCCGCATTCAGCGCTGCATCACGCTCCATGCAAAAGGGCTGATATGTGAGGCCGATACGCTCGGTTCCTGTGGCTATTT
GTACATCGTAATTTATCCGGCGTCTGCAACAACCGCATAA