Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3807179..3807858 Replicon chromosome
Accession NZ_CP011591
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag AB190_RS19755 Protein ID WP_047743670.1
Coordinates 3807517..3807858 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag AB190_RS19750 Protein ID WP_047743668.1
Coordinates 3807179..3807496 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB190_RS19710 3802692..3803555 + 864 WP_047743651.1 GTPase family protein -
AB190_RS19715 3803647..3804468 + 822 WP_047743653.1 DUF945 domain-containing protein -
AB190_RS19720 3804685..3805386 + 702 WP_047743655.1 WYL domain-containing protein -
AB190_RS19725 3805427..3805663 + 237 WP_047743663.1 hypothetical protein -
AB190_RS19730 3805663..3806103 + 441 WP_047743664.1 hypothetical protein -
AB190_RS19735 3806127..3806594 + 468 WP_047743665.1 hypothetical protein -
AB190_RS19740 3806671..3806910 + 240 WP_047743666.1 DUF905 domain-containing protein -
AB190_RS19745 3807008..3807160 + 153 Protein_3562 DUF987 family protein -
AB190_RS19750 3807179..3807496 + 318 WP_047743668.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AB190_RS19755 3807517..3807858 + 342 WP_047743670.1 TA system toxin CbtA family protein Toxin
AB190_RS19760 3808151..3809188 - 1038 WP_047743673.1 tyrosine-type recombinase/integrase -
AB190_RS19765 3809192..3809758 - 567 WP_047743676.1 PH domain-containing protein -
AB190_RS19770 3809775..3810371 - 597 WP_047743678.1 phage repressor protein CI -
AB190_RS19775 3810472..3810693 + 222 WP_015460844.1 regulator from bacteriophage origin -
AB190_RS19780 3810724..3811227 + 504 WP_047743681.1 phage regulatory CII family protein -
AB190_RS19785 3811237..3811431 + 195 WP_047743683.1 DUF2724 domain-containing protein -
AB190_RS19790 3811421..3811849 + 429 WP_013097409.1 hypothetical protein -
AB190_RS19795 3811849..3812250 + 402 WP_047743685.1 hypothetical protein -
AB190_RS19800 3812317..3812550 + 234 WP_047743687.1 DUF2732 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3772113..3839313 67200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13110.17 Da        Isoelectric Point: 10.3379

>T54651 WP_047743670.1 NZ_CP011591:3807517-3807858 [Enterobacter asburiae]
MKTLPATTQRAVRRCLSPVAVWQMLLTRLLEQHYGLTLNDTLFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRKNSVR

Download         Length: 342 bp

>T54651 NZ_CP011591:3807517-3807858 [Enterobacter asburiae]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAGGCGCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACTGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ACGCTGGGATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAGTCCCCTTACCTTCGGGCTGTCGATATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGACAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11973.52 Da        Isoelectric Point: 6.9465

>AT54651 WP_047743668.1 NZ_CP011591:3807179-3807496 [Enterobacter asburiae]
MSNTIWGLQREFSPRLGARLVQEGNRLHYLADRASITGKFSDTECRKLDETFPHFIRQMESMLSTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT54651 NZ_CP011591:3807179-3807496 [Enterobacter asburiae]
ATGAGCAATACTATTTGGGGCCTGCAGCGGGAGTTCAGCCCCCGTTTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCCGATCGGGCCAGCATCACCGGCAAGTTCAGCGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGAGCACCGGTGAACTCAGCCCCCAACATGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References