Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2581182..2581698 Replicon chromosome
Accession NZ_CP011591
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name relE Uniprot ID A0A143HZU1
Locus tag AB190_RS13815 Protein ID WP_047742994.1
Coordinates 2581182..2581466 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag AB190_RS13820 Protein ID WP_008501400.1
Coordinates 2581456..2581698 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB190_RS13800 2576396..2578039 + 1644 WP_047742991.1 alpha,alpha-phosphotrehalase -
AB190_RS13805 2578416..2580554 + 2139 WP_023310191.1 anaerobic ribonucleoside-triphosphate reductase -
AB190_RS13810 2580714..2581178 + 465 WP_047742993.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AB190_RS13815 2581182..2581466 - 285 WP_047742994.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AB190_RS13820 2581456..2581698 - 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AB190_RS13825 2581776..2583686 - 1911 WP_047742995.1 BglG family transcription antiterminator -
AB190_RS13830 2583709..2584845 - 1137 WP_047742997.1 lactonase family protein -
AB190_RS13835 2584960..2585700 - 741 WP_023310186.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10849.70 Da        Isoelectric Point: 10.4622

>T54648 WP_047742994.1 NZ_CP011591:c2581466-2581182 [Enterobacter asburiae]
MTYELAFDPRALKEWSKLGQTVKGQFKKKLADVLVNPRVESARLHGLPDCYKIKLRTQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T54648 NZ_CP011591:c2581466-2581182 [Enterobacter asburiae]
ATGACTTATGAACTGGCATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGCAGACTGTAAAAGGCCAGTTTAA
GAAGAAACTTGCGGACGTGCTGGTGAACCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGAACGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
CGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT54648 WP_008501400.1 NZ_CP011591:c2581698-2581456 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT54648 NZ_CP011591:c2581698-2581456 [Enterobacter asburiae]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GCGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143HZU1

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References