Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2036317..2036937 Replicon chromosome
Accession NZ_CP011591
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag AB190_RS11300 Protein ID WP_008499287.1
Coordinates 2036719..2036937 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag AB190_RS11295 Protein ID WP_008499288.1
Coordinates 2036317..2036691 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB190_RS11285 2031443..2032636 + 1194 WP_023310601.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AB190_RS11290 2032659..2035805 + 3147 WP_047742664.1 multidrug efflux RND transporter permease subunit AcrB -
AB190_RS11295 2036317..2036691 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
AB190_RS11300 2036719..2036937 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
AB190_RS11305 2037143..2037694 + 552 WP_023310599.1 maltose O-acetyltransferase -
AB190_RS11310 2037812..2038279 + 468 WP_023310598.1 hypothetical protein -
AB190_RS11315 2038251..2039711 - 1461 WP_047742666.1 PLP-dependent aminotransferase family protein -
AB190_RS11320 2039813..2040523 + 711 WP_047742667.1 GNAT family N-acetyltransferase -
AB190_RS11325 2040520..2040660 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AB190_RS11330 2040663..2040923 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T54647 WP_008499287.1 NZ_CP011591:2036719-2036937 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T54647 NZ_CP011591:2036719-2036937 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTCGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAGCTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT54647 WP_008499288.1 NZ_CP011591:2036317-2036691 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT54647 NZ_CP011591:2036317-2036691 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References