Detailed information of TA system TA054646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): KacT-ataR/DUF1778(antitoxin)
• Location: 1442694..1443491
• Replicon: chromosome
• Accession: NZ_CP011591
• Organism: Enterobacter asburiae strain CAV1043

Toxin (Protein)

• Gene name: KacT
• Uniprot ID: -
• Locus tag: AB190_RS08465
• Protein ID: WP_196298287.1
• Coordinates: 1442694..1443194 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: AB190_RS08470
• Protein ID: WP_023311079.1
• Coordinates: 1443222..1443491 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB190_RS08435	1438277..1438966	+	690	WP_047742244.1	pyrimidine utilization protein B	-
AB190_RS08440	1438978..1439364	+	387	WP_010429508.1	pyrimidine utilization protein C	-
AB190_RS08445	1439372..1440172	+	801	WP_047742246.1	pyrimidine utilization protein D	-
AB190_RS08450	1440182..1440772	+	591	WP_045354561.1	malonic semialdehyde reductase	-
AB190_RS08455	1440782..1441276	+	495	WP_047742247.1	pyrimidine utilization flavin reductase protein F	-
AB190_RS08460	1441298..1442620	+	1323	WP_047742249.1	pyrimidine utilization transport protein G	-
AB190_RS08465	1442694..1443194	-	501	WP_196298287.1	GNAT family N-acetyltransferase	Toxin
AB190_RS08470	1443222..1443491	-	270	WP_023311079.1	DUF1778 domain-containing protein	Antitoxin
AB190_RS08475	1443553..1444470	-	918	WP_047742252.1	DMT family transporter	-
AB190_RS08480	1444588..1444758	-	171	WP_023311077.1	general stress protein	-
AB190_RS08485	1445150..1445746	+	597	WP_023311076.1	NAD(P)H:quinone oxidoreductase	-
AB190_RS08490	1445767..1445994	+	228	WP_008499832.1	YccJ family protein	-
AB190_RS08495	1446028..1447269	-	1242	WP_047742254.1	bifunctional glucose-1-phosphatase/inositol phosphatase	-
AB190_RS08500	1447422..1447865	+	444	WP_047742255.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (2-88)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 18975.63 Da
• Isoelectric Point: 7.9347

>T54646 WP_196298287.1 NZ_CP011591:c1443194-1442694 [Enterobacter asburiae]
MLSEGTDYDFEDFDCGEPSLNAFLAEHLVRQHNGRILRAYLLKERDRPRVLGYYTLSGSCFERAMHPSKTQQRRIPYINV
PSVTLGRLAVDKPLQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKQGFIPLTGENSHSLFFPTKSIE
RLFEQE

Nucleotide

• Length: 501 bp

>T54646 NZ_CP011591:c1443194-1442694 [Enterobacter asburiae]
ATGTTATCAGAGGGAACCGATTATGACTTCGAGGATTTTGATTGTGGCGAACCCTCGCTAAATGCCTTCCTTGCTGAACA
TCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGCCTACCTGCTTAAAGAGCGCGATCGTCCGCGTGTCCTGGGTTATT
ACACGTTATCGGGAAGCTGTTTTGAAAGAGCGATGCATCCTTCTAAGACTCAGCAGCGCCGGATCCCTTATATCAACGTA
CCCAGCGTGACGCTGGGACGTCTGGCTGTAGATAAACCACTACAGGGAAACGAGTGGGGAACAACGCTCGTCGCGCATGC
TATGCGCGTTGTCTACCTGGCTTCACAGGCTGTGGGGGTACACGGAATATTTGTTGATGCCCTTAACGAGCGGGCAAAAC
GATTTTATCTGAAGCAGGGCTTTATCCCGCTGACAGGTGAAAACAGCCATTCTTTGTTCTTCCCTACAAAATCTATCGAA
CGGCTGTTTGAGCAAGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10249.72 Da
• Isoelectric Point: 5.8836

>AT54646 WP_023311079.1 NZ_CP011591:c1443491-1443222 [Enterobacter asburiae]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWTAVMDAIDNPPEPNERLKR
AAKRLRNME

Nucleotide

• Length: 270 bp

>AT54646 NZ_CP011591:c1443491-1443222 [Enterobacter asburiae]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATTGAGCAGCACCGTCGTC
TCGTATTAAACGAAGCATCATGGACTGCGGTGATGGATGCCATCGACAATCCGCCTGAGCCAAATGAACGCCTGAAACGA
GCAGCAAAACGGCTTCGAAACATGGAGTGA