Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 14145..14664 Replicon plasmid pCAV1043-58
Accession NZ_CP011588
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name parE Uniprot ID A0A9E7BHM1
Locus tag AB190_RS00435 Protein ID WP_047389778.1
Coordinates 14145..14429 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A9E7BH21
Locus tag AB190_RS00440 Protein ID WP_047389775.1
Coordinates 14422..14664 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB190_RS26095 9301..9393 - 93 Protein_11 recombinase family protein -
AB190_RS00400 10115..10306 + 192 WP_047741489.1 hypothetical protein -
AB190_RS00405 10339..10635 + 297 WP_047741491.1 hypothetical protein -
AB190_RS00410 10650..11609 - 960 WP_047741493.1 tyrosine-type recombinase/integrase -
AB190_RS00415 11668..12363 - 696 WP_047389784.1 IS6-like element ISEas1 family transposase -
AB190_RS26100 12674..12976 + 303 WP_052132604.1 hypothetical protein -
AB190_RS00425 13127..13747 + 621 WP_047389782.1 ParA family protein -
AB190_RS00430 13786..14013 + 228 WP_047389780.1 DNA partition complex ParG -
AB190_RS00435 14145..14429 - 285 WP_047389778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AB190_RS00440 14422..14664 - 243 WP_047389775.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AB190_RS00455 16950..17192 + 243 WP_052132603.1 hypothetical protein -
AB190_RS00465 18009..18269 - 261 WP_047389771.1 hypothetical protein -
AB190_RS00470 18380..19198 - 819 WP_040080118.1 SprT-like domain-containing protein -
AB190_RS00475 19201..19434 - 234 WP_047389767.1 antirestriction protein ArdR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..58427 58427
- inside IScluster/Tn - - 5422..16341 10919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10965.46 Da        Isoelectric Point: 6.2103

>T54635 WP_047389778.1 NZ_CP011588:c14429-14145 [Enterobacter asburiae]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHAVSGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T54635 NZ_CP011588:c14429-14145 [Enterobacter asburiae]
GTGTATAAACTCACCGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGATCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTTGCCGGAATGCCAGATATGGGACGTGACTACCATG
CCGTTTCTGGTGTGATGCGCATTGAATTTCAGCGACACGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCA
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8949.09 Da        Isoelectric Point: 7.0142

>AT54635 WP_047389775.1 NZ_CP011588:c14664-14422 [Enterobacter asburiae]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVVRQAVITGLESGESSLSLRDIAEKRKLRHRV

Download         Length: 243 bp

>AT54635 NZ_CP011588:c14664-14422 [Enterobacter asburiae]
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAACTCGATTCGTTTATCAGTCGATTAATAGACAGTGGCCGTTATGG
CTCTGCGAGTGAAGTTATGCGTTCTGCTCTGCGATTACTGGAGCAACAGGAAACAAATGATGAAGTTGTTCGCCAGGCAG
TAATTACCGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGAAAAAAGAAAGCTGAGACATCGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References