Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3366423..3367080 Replicon chromosome
Accession NZ_CP011584
Organism Enterobacter hormaechei strain CAV1668

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag ABY64_RS16680 Protein ID WP_017382887.1
Coordinates 3366423..3366833 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ABY64_RS16685 Protein ID WP_003863437.1
Coordinates 3366814..3367080 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABY64_RS16660 3362421..3364154 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
ABY64_RS16665 3364160..3364873 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ABY64_RS16670 3364902..3365798 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
ABY64_RS16675 3365900..3366421 + 522 WP_015571793.1 flavodoxin FldB -
ABY64_RS16680 3366423..3366833 - 411 WP_017382887.1 protein YgfX Toxin
ABY64_RS16685 3366814..3367080 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ABY64_RS16690 3367375..3368355 + 981 WP_032619082.1 tRNA-modifying protein YgfZ -
ABY64_RS16695 3368467..3369126 - 660 WP_003863433.1 hemolysin III family protein -
ABY64_RS16700 3369393..3370124 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
ABY64_RS16705 3370241..3371674 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T54629 WP_017382887.1 NZ_CP011584:c3366833-3366423 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T54629 NZ_CP011584:c3366833-3366423 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT54629 WP_003863437.1 NZ_CP011584:c3367080-3366814 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT54629 NZ_CP011584:c3367080-3366814 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References