Detailed information of TA system TA054615

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 205335..206053
• Replicon: chromosome
• Accession: NZ_CP011584
• Organism: Enterobacter hormaechei strain CAV1668

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: ABY64_RS01680
• Protein ID: WP_047715719.1
• Coordinates: 205733..206053 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: ABY64_RS01675
• Protein ID: WP_047715718.1
• Coordinates: 205335..205700 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABY64_RS01645	200633..201265	-	633	WP_028016395.1	inovirus Gp2 family protein	-
ABY64_RS01650	201756..202649	+	894	WP_047715709.1	50S ribosome-binding GTPase	-
ABY64_RS01655	202937..203614	+	678	WP_047715710.1	hypothetical protein	-
ABY64_RS01660	203714..204532	+	819	WP_047715712.1	DUF945 domain-containing protein	-
ABY64_RS01665	204603..205073	+	471	WP_047715715.1	DNA repair protein RadC	-
ABY64_RS01670	205082..205303	+	222	WP_047715716.1	DUF987 family protein	-
ABY64_RS01675	205335..205700	+	366	WP_047715718.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ABY64_RS01680	205733..206053	+	321	WP_047715719.1	TA system toxin CbtA family protein	Toxin
ABY64_RS01685	206166..206999	+	834	WP_047715720.1	DUF4942 domain-containing protein	-
ABY64_RS01690	207368..208564	+	1197	WP_047715722.1	integrase arm-type DNA-binding domain-containing protein	-
ABY64_RS01695	208582..209550	+	969	WP_022649395.1	IS5 family transposase	-
ABY64_RS01700	209817..210380	-	564	WP_017692853.1	Polarity suppression protein	-
ABY64_RS01705	210409..210627	-	219	WP_023323621.1	ogr/Delta-like zinc finger family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	208582..209550	968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12128.89 Da
• Isoelectric Point: 5.9559

>T54615 WP_047715719.1 NZ_CP011584:205733-206053 [Enterobacter hormaechei]
MHISTIPATVLVASRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDSAIQEHIEAGITLADAVNFLVERYELIRTDRKGF
TWQEQTPFLTAIDILRARRATGLMNI

Nucleotide

• Length: 321 bp

>T54615 NZ_CP011584:205733-206053 [Enterobacter hormaechei]
ATGCATATTTCAACTATACCGGCCACGGTACTGGTTGCGTCACGCCTGTCGCCCGTACAGGTCTGGCAACAACTGTTAAC
CTATCTGCTTGAGCATCATTACGGCCTTACGCTCAACGACACACCATTCCATGATGATTCAGCCATCCAAGAACATATCG
AAGCAGGAATAACACTGGCTGATGCGGTGAATTTTCTGGTTGAACGCTATGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAAGAGCAGACACCATTTCTGACCGCTATCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATGAATATATA
A

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13415.12 Da
• Isoelectric Point: 5.5286

>AT54615 WP_047715718.1 NZ_CP011584:205335-205700 [Enterobacter hormaechei]
MQSTTLYGSSAENASCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDDEALRLDLAFPLIMEQLERMLTTGE
LDPRSQHCATLHHNGLVCEADTLGSHGYVYIAIYPQSAVTR

Nucleotide

• Length: 366 bp

>AT54615 NZ_CP011584:205335-205700 [Enterobacter hormaechei]
ATGCAATCGACCACCTTATACGGCTCATCAGCGGAGAACGCATCCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAAGAAGGCAACCGTCTCTACTTTCTGGCTGATCGGGCTGGTTTTAATGGCTCATTCA
GTGACGATGAAGCATTGCGTCTGGACCTGGCGTTTCCACTGATAATGGAACAGCTGGAGCGGATGCTTACAACTGGAGAG
CTCGATCCCCGCAGCCAGCATTGCGCCACGCTGCATCACAACGGACTGGTCTGTGAAGCTGACACTCTCGGCTCTCATGG
TTACGTTTACATCGCTATTTATCCCCAGTCAGCCGTAACTAGGTAA