Detailed information of TA system TA054614

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 4730198..4730916
• Replicon: chromosome
• Accession: NZ_CP011581
• Organism: Enterobacter hormaechei strain CAV1411

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: ABY65_RS23330
• Protein ID: WP_047715719.1
• Coordinates: 4730198..4730518 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: ABY65_RS23335
• Protein ID: WP_047715718.1
• Coordinates: 4730551..4730916 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABY65_RS23305	4725623..4725841	+	219	WP_023323621.1	ogr/Delta-like zinc finger family protein	-
ABY65_RS23310	4725870..4726433	+	564	WP_017692853.1	Polarity suppression protein	-
ABY65_RS23315	4726700..4727668	-	969	WP_022649395.1	IS5 family transposase	-
ABY65_RS23320	4727686..4728882	-	1197	WP_047715722.1	integrase arm-type DNA-binding domain-containing protein	-
ABY65_RS23325	4729252..4730085	-	834	WP_047715720.1	DUF4942 domain-containing protein	-
ABY65_RS23330	4730198..4730518	-	321	WP_047715719.1	TA system toxin CbtA family protein	Toxin
ABY65_RS23335	4730551..4730916	-	366	WP_047715718.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ABY65_RS23340	4730948..4731169	-	222	WP_047715716.1	DUF987 family protein	-
ABY65_RS23345	4731178..4731648	-	471	WP_047715715.1	DNA repair protein RadC	-
ABY65_RS23350	4731719..4732537	-	819	WP_047715712.1	DUF945 domain-containing protein	-
ABY65_RS23355	4732637..4733314	-	678	WP_047715710.1	hypothetical protein	-
ABY65_RS23360	4733602..4734495	-	894	WP_047715709.1	50S ribosome-binding GTPase	-
ABY65_RS23365	4734986..4735618	+	633	WP_028016395.1	inovirus Gp2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	fosA	-	4710107..4757814	47707
	-	flank	IS/Tn	-	-	4726700..4727668	968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12128.89 Da
• Isoelectric Point: 5.9559

>T54614 WP_047715719.1 NZ_CP011581:c4730518-4730198 [Enterobacter hormaechei]
MHISTIPATVLVASRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDSAIQEHIEAGITLADAVNFLVERYELIRTDRKGF
TWQEQTPFLTAIDILRARRATGLMNI

Nucleotide

• Length: 321 bp

>T54614 NZ_CP011581:c4730518-4730198 [Enterobacter hormaechei]
ATGCATATTTCAACTATACCGGCCACGGTACTGGTTGCGTCACGCCTGTCGCCCGTACAGGTCTGGCAACAACTGTTAAC
CTATCTGCTTGAGCATCATTACGGCCTTACGCTCAACGACACACCATTCCATGATGATTCAGCCATCCAAGAACATATCG
AAGCAGGAATAACACTGGCTGATGCGGTGAATTTTCTGGTTGAACGCTATGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAAGAGCAGACACCATTTCTGACCGCTATCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATGAATATATA
A

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13415.12 Da
• Isoelectric Point: 5.5286

>AT54614 WP_047715718.1 NZ_CP011581:c4730916-4730551 [Enterobacter hormaechei]
MQSTTLYGSSAENASCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDDEALRLDLAFPLIMEQLERMLTTGE
LDPRSQHCATLHHNGLVCEADTLGSHGYVYIAIYPQSAVTR

Nucleotide

• Length: 366 bp

>AT54614 NZ_CP011581:c4730916-4730551 [Enterobacter hormaechei]
ATGCAATCGACCACCTTATACGGCTCATCAGCGGAGAACGCATCCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAAGAAGGCAACCGTCTCTACTTTCTGGCTGATCGGGCTGGTTTTAATGGCTCATTCA
GTGACGATGAAGCATTGCGTCTGGACCTGGCGTTTCCACTGATAATGGAACAGCTGGAGCGGATGCTTACAACTGGAGAG
CTCGATCCCCGCAGCCAGCATTGCGCCACGCTGCATCACAACGGACTGGTCTGTGAAGCTGACACTCTCGGCTCTCATGG
TTACGTTTACATCGCTATTTATCCCCAGTCAGCCGTAACTAGGTAA