Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2510994..2511599 Replicon chromosome
Accession NZ_CP011581
Organism Enterobacter hormaechei strain CAV1411

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag ABY65_RS12795 Protein ID WP_012906750.1
Coordinates 2511420..2511599 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag ABY65_RS12790 Protein ID WP_032619507.1
Coordinates 2510994..2511398 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABY65_RS12765 2506497..2507048 + 552 WP_032619504.1 phage tail protein I -
ABY65_RS24035 2507051..2509228 + 2178 WP_050019395.1 phage tail protein -
ABY65_RS12780 2509228..2509806 + 579 WP_032619505.1 tail fiber assembly protein -
ABY65_RS12785 2509883..2510953 + 1071 WP_032619506.1 glycosyltransferase family 9 protein -
ABY65_RS12790 2510994..2511398 - 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ABY65_RS12795 2511420..2511599 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
ABY65_RS12800 2511883..2513157 + 1275 WP_032619509.1 ATP-binding protein -
ABY65_RS12805 2513154..2513687 + 534 WP_032619510.1 glycosyltransferase family 2 protein -
ABY65_RS12810 2514589..2515344 + 756 Protein_2347 DUF4225 domain-containing protein -
ABY65_RS12815 2515347..2515670 + 324 WP_017384434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2466223..2517972 51749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T54605 WP_012906750.1 NZ_CP011581:c2511599-2511420 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T54605 NZ_CP011581:c2511599-2511420 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTTAGAGTGAAAGGCAGTCATCACCAGTT
TAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATTA
AAAAACAGGCGGGGCTCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT54605 WP_032619507.1 NZ_CP011581:c2511398-2510994 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT54605 NZ_CP011581:c2511398-2510994 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGAAGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCCGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAGTACGCCGGTGCGGTATGGGCCCTAGTTGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTACCCTCATTACTGATCCGACGTATTGATCA
GTTTGTGGCCGCGCATCCTGAATATGGAAGCCGTTCGGGCTTCCTTTCTCGCGTCGCTGCTGACAAGGTTATTAATCAAC
GATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References