Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1564278..1564935 Replicon chromosome
Accession NZ_CP011581
Organism Enterobacter hormaechei strain CAV1411

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag ABY65_RS08295 Protein ID WP_017382887.1
Coordinates 1564525..1564935 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ABY65_RS08290 Protein ID WP_003863437.1
Coordinates 1564278..1564544 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABY65_RS08270 1559684..1561117 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
ABY65_RS08275 1561234..1561965 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
ABY65_RS08280 1562232..1562891 + 660 WP_003863433.1 hemolysin III family protein -
ABY65_RS08285 1563003..1563983 - 981 WP_032619082.1 tRNA-modifying protein YgfZ -
ABY65_RS08290 1564278..1564544 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ABY65_RS08295 1564525..1564935 + 411 WP_017382887.1 protein YgfX Toxin
ABY65_RS08300 1564937..1565458 - 522 WP_015571793.1 flavodoxin FldB -
ABY65_RS08305 1565560..1566456 + 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
ABY65_RS08310 1566485..1567198 + 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ABY65_RS08315 1567204..1568937 + 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T54602 WP_017382887.1 NZ_CP011581:1564525-1564935 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T54602 NZ_CP011581:1564525-1564935 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT54602 WP_003863437.1 NZ_CP011581:1564278-1564544 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT54602 NZ_CP011581:1564278-1564544 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References