Detailed information of TA system TA054601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 984728..985344
• Replicon: chromosome
• Accession: NZ_CP011581
• Organism: Enterobacter hormaechei strain CAV1411

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ABY65_RS05530
• Protein ID: WP_015569913.1
• Coordinates: 984973..985344 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: ABY65_RS05525
• Protein ID: WP_015569912.1
• Coordinates: 984728..984970 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABY65_RS05495	979787..980587	+	801	WP_003861944.1	DeoR/GlpR family DNA-binding transcription regulator	-
ABY65_RS05500	980706..981305	+	600	WP_003861947.1	glucose-1-phosphatase	-
ABY65_RS05505	981299..982180	+	882	WP_003861949.1	virulence factor BrkB family protein	-
ABY65_RS05510	982177..982614	+	438	WP_015569909.1	D-tyrosyl-tRNA(Tyr) deacylase	-
ABY65_RS05515	982659..983600	+	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
ABY65_RS05520	983609..984529	-	921	WP_015569911.1	alpha/beta hydrolase	-
ABY65_RS05525	984728..984970	+	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
ABY65_RS05530	984973..985344	+	372	WP_015569913.1	PIN domain-containing protein	Toxin
ABY65_RS05535	985384..986313	-	930	WP_003861956.1	formate dehydrogenase accessory protein FdhE	-
ABY65_RS05540	986310..986945	-	636	WP_015569914.1	formate dehydrogenase cytochrome b556 subunit	-
ABY65_RS05545	986942..987844	-	903	WP_014072386.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13767.90 Da
• Isoelectric Point: 6.4882

>T54601 WP_015569913.1 NZ_CP011581:984973-985344 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T54601 NZ_CP011581:984973-985344 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT54601 WP_015569912.1 NZ_CP011581:984728-984970 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT54601 NZ_CP011581:984728-984970 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3