Detailed information of TA system TA054599

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 404410..405129
• Replicon: chromosome
• Accession: NZ_CP011581
• Organism: Enterobacter hormaechei strain CAV1411

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A144XIR2
• Locus tag: ABY65_RS02710
• Protein ID: WP_023305176.1
• Coordinates: 404809..405129 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: ABY65_RS02705
• Protein ID: WP_032620726.1
• Coordinates: 404410..404775 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABY65_RS02680	400708..401142	+	435	WP_044488933.1	hypothetical protein	-
ABY65_RS24015	401255..402094	+	840	WP_050595703.1	hypothetical protein	-
ABY65_RS24185	402153..402344	+	192	WP_023305181.1	hypothetical protein	-
ABY65_RS02690	402787..403608	+	822	WP_032620720.1	DUF945 domain-containing protein	-
ABY65_RS02695	403678..404148	+	471	WP_032620722.1	DNA repair protein RadC	-
ABY65_RS02700	404157..404378	+	222	WP_032620724.1	DUF987 domain-containing protein	-
ABY65_RS02705	404410..404775	+	366	WP_032620726.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ABY65_RS02710	404809..405129	+	321	WP_023305176.1	TA system toxin CbtA family protein	Toxin
ABY65_RS02715	405332..405913	+	582	WP_017383635.1	hypothetical protein	-
ABY65_RS02720	405915..406106	-	192	WP_032620729.1	toxin-antitoxin system HicB family antitoxin	-
ABY65_RS02725	406243..406584	+	342	WP_032620730.1	SymE family type I addiction module toxin	-
ABY65_RS02730	406643..407671	+	1029	WP_071842900.1	virulence RhuM family protein	-
ABY65_RS02735	407935..408420	+	486	WP_017383637.1	type VI secretion system tube protein Hcp	-
ABY65_RS24190	408430..408795	+	366	WP_023302859.1	DUF2778 domain-containing protein	-
ABY65_RS02740	408858..409379	+	522	WP_017383638.1	hypothetical protein	-
ABY65_RS02745	409412..409855	-	444	WP_017383639.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	379167..413734	34567

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12190.77 Da
• Isoelectric Point: 5.9559

>T54599 WP_023305176.1 NZ_CP011581:404809-405129 [Enterobacter hormaechei]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS

Nucleotide

• Length: 321 bp

>T54599 NZ_CP011581:404809-405129 [Enterobacter hormaechei]
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13574.29 Da
• Isoelectric Point: 6.4673

>AT54599 WP_032620726.1 NZ_CP011581:404410-404775 [Enterobacter hormaechei]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Nucleotide

• Length: 366 bp

>AT54599 NZ_CP011581:404410-404775 [Enterobacter hormaechei]
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA

Structures

Toxin

• AlphaFold DB: A0A144XIR2