Detailed information of TA system TA054578

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4171474..4172131
• Replicon: chromosome
• Accession: NZ_CP011574
• Organism: Klebsiella aerogenes strain CAV1320

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ABY61_RS19660
• Protein ID: WP_045414364.1
• Coordinates: 4171721..4172131 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0H3FJK6
• Locus tag: ABY61_RS19655
• Protein ID: WP_015369791.1
• Coordinates: 4171474..4171740 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABY61_RS19630	4166649..4168082	-	1434	WP_015369787.1	6-phospho-beta-glucosidase BglA	-
ABY61_RS19635	4168196..4168930	-	735	WP_015703423.1	MurR/RpiR family transcriptional regulator	-
ABY61_RS19640	4168981..4169292	+	312	WP_015369789.1	N(4)-acetylcytidine aminohydrolase	-
ABY61_RS19645	4169457..4170116	+	660	WP_008806429.1	hemolysin III family protein	-
ABY61_RS19650	4170267..4171250	-	984	WP_015369790.1	tRNA-modifying protein YgfZ	-
ABY61_RS19655	4171474..4171740	+	267	WP_015369791.1	FAD assembly factor SdhE	Antitoxin
ABY61_RS19660	4171721..4172131	+	411	WP_045414364.1	protein YgfX	Toxin
ABY61_RS19665	4172139..4172660	-	522	WP_015369793.1	flavodoxin FldB	-
ABY61_RS19670	4172761..4173657	+	897	WP_032715787.1	site-specific tyrosine recombinase XerD	-
ABY61_RS19675	4173680..4174393	+	714	WP_015369795.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ABY61_RS19680	4174399..4176132	+	1734	WP_047740330.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15905.72 Da
• Isoelectric Point: 10.0200

>T54578 WP_045414364.1 NZ_CP011574:4171721-4172131 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVMQKPAHD

Nucleotide

• Length: 411 bp

>T54578 NZ_CP011574:4171721-4172131 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCATGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGATGCAAAAACCGG
CGCACGACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10579.09 Da
• Isoelectric Point: 5.6963

>AT54578 WP_015369791.1 NZ_CP011574:4171474-4171740 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT54578 NZ_CP011574:4171474-4171740 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3FJK6