Detailed information of TA system TA054575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3403335..3404356
• Replicon: chromosome
• Accession: NZ_CP011574
• Organism: Klebsiella aerogenes strain CAV1320

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: A0A0G9UXE3
• Locus tag: ABY61_RS15955
• Protein ID: WP_032706547.1
• Coordinates: 3403781..3404356 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: ABY61_RS15950
• Protein ID: WP_047043205.1
• Coordinates: 3403335..3403781 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABY61_RS15925	3398856..3399635	+	780	WP_047740220.1	MBL fold metallo-hydrolase	-
ABY61_RS15930	3399657..3400610	+	954	WP_047740788.1	helix-turn-helix domain-containing protein	-
ABY61_RS15935	3400607..3401656	-	1050	WP_032709443.1	NAD(P)-dependent alcohol dehydrogenase	-
ABY61_RS15940	3401814..3402116	-	303	WP_047740221.1	antibiotic biosynthesis monooxygenase	-
ABY61_RS15945	3402117..3403124	-	1008	WP_047740222.1	zinc-binding alcohol dehydrogenase family protein	-
ABY61_RS15950	3403335..3403781	+	447	WP_047043205.1	helix-turn-helix domain-containing protein	Antitoxin
ABY61_RS15955	3403781..3404356	+	576	WP_032706547.1	PIN domain-containing protein	Toxin
ABY61_RS15965	3404661..3405857	+	1197	WP_042893658.1	hypothetical protein	-
ABY61_RS15970	3406142..3407179	-	1038	WP_047058851.1	virulence RhuM family protein	-
ABY61_RS15975	3407403..3407691	-	289	Protein_3144	SymE family type I addiction module toxin	-
ABY61_RS15980	3407763..3408065	-	303	WP_047043163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• SinI-like, DNA-binding domain (79-126)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21688.29 Da
• Isoelectric Point: 6.2900

>T54575 WP_032706547.1 NZ_CP011574:3403781-3404356 [Klebsiella aerogenes]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRFIHDEWCRNLLINRPDIAPEALRRTVDLMNAALPDANVTGF
AGLINGLVLPDPDDRHVLAAAIRAKAEIIVTLNHKDFPAESLLPFEIETLHPDVFISDLFDLNHALALEAVRRQRQSLKH
PPMTVDEFLEMLLKQGLPMTVKELANYQYAI

Nucleotide

• Length: 576 bp

>T54575 NZ_CP011574:3403781-3404356 [Klebsiella aerogenes]
ATGCGACATTCACCTTATCCGGTGATTTTAGATGCTTGTGTATTATATCCAGCACGGCTCAGGGATTTATTAATGCACTT
AGGGATCGCTGGACTTTATCAACCAAAATGGAGCCGCTTCATTCACGATGAATGGTGCAGGAATCTTCTTATAAATCGGC
CTGATATAGCACCTGAAGCGCTGCGTCGTACCGTTGATCTCATGAATGCAGCTTTACCGGATGCTAATGTAACGGGTTTT
GCAGGATTAATTAACGGACTAGTTTTACCCGACCCTGACGATCGGCATGTCCTTGCTGCGGCAATCAGAGCGAAGGCTGA
AATTATCGTTACGTTAAATCATAAAGACTTTCCAGCAGAATCATTGCTTCCATTTGAAATTGAAACACTTCATCCTGATG
TATTCATATCGGACCTGTTTGACCTTAATCATGCTCTGGCGTTGGAGGCGGTGAGAAGGCAGCGGCAGTCTCTCAAGCAT
CCTCCAATGACCGTCGATGAGTTCCTGGAGATGCTGCTAAAGCAGGGCTTGCCGATGACGGTAAAAGAGTTAGCCAATTA
CCAGTACGCCATATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16698.27 Da
• Isoelectric Point: 6.4921

>AT54575 WP_047043205.1 NZ_CP011574:3403335-3403781 [Klebsiella aerogenes]
MTKLNLPNPLESELAQRGQRELAAYLSTHLETQRIAIVGEDDKTHTIELPTSALTMLMEILGELACGNAVQIVPVHAELT
TQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQALADQAQDLGMY

Nucleotide

• Length: 447 bp

>AT54575 NZ_CP011574:3403335-3403781 [Klebsiella aerogenes]
ATGACTAAACTGAACCTTCCGAACCCGCTGGAGAGTGAACTTGCCCAGCGCGGGCAGCGTGAGCTGGCGGCATACCTTTC
TACTCATCTTGAAACGCAGCGTATTGCGATTGTGGGTGAAGATGACAAAACTCATACCATTGAGTTGCCAACCAGCGCTC
TGACTATGCTGATGGAGATCCTTGGGGAATTGGCTTGTGGCAACGCGGTGCAGATTGTTCCTGTTCATGCTGAACTCACC
ACCCAGGAAGCAGCGAATATCCTCAATGTTTCTCGTCCGCATATGGTTAAACTGCTGGAAGCGAGGAAGCTTCCATTTCA
TAAAACTGGACGCCATCGCCGGGTTCTGTTTGCCGATCTGATGGAGTATAAAAAACGTAGGGAACAGGAAAGCCTGGACG
CGATGCAAGCGCTGGCGGATCAGGCGCAGGACTTAGGGATGTATTAA

Structures

Toxin

• AlphaFold DB: A0A0G9UXE3