Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4397281..4397886 Replicon chromosome
Accession NZ_CP011572
Organism Enterobacter hormaechei strain CAV1311

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag ABY62_RS21770 Protein ID WP_012906750.1
Coordinates 4397707..4397886 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag ABY62_RS21765 Protein ID WP_032619507.1
Coordinates 4397281..4397685 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABY62_RS21740 4392784..4393335 + 552 WP_032619504.1 phage tail protein I -
ABY62_RS24050 4393338..4395515 + 2178 WP_050019395.1 phage tail protein -
ABY62_RS21755 4395515..4396093 + 579 WP_032619505.1 tail fiber assembly protein -
ABY62_RS21760 4396170..4397240 + 1071 WP_032619506.1 glycosyltransferase family 9 protein -
ABY62_RS21765 4397281..4397685 - 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ABY62_RS21770 4397707..4397886 - 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
ABY62_RS21775 4398170..4399444 + 1275 WP_032619509.1 ATP-binding protein -
ABY62_RS21780 4399441..4399974 + 534 WP_032619510.1 glycosyltransferase family 2 protein -
ABY62_RS21785 4400876..4401631 + 756 Protein_4114 DUF4225 domain-containing protein -
ABY62_RS21790 4401634..4401957 + 324 WP_017384434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 4348521..4404259 55738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T54556 WP_012906750.1 NZ_CP011572:c4397886-4397707 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T54556 NZ_CP011572:c4397886-4397707 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTTAGAGTGAAAGGCAGTCATCACCAGTT
TAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATTA
AAAAACAGGCGGGGCTCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT54556 WP_032619507.1 NZ_CP011572:c4397685-4397281 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT54556 NZ_CP011572:c4397685-4397281 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGAAGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCCGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAGTACGCCGGTGCGGTATGGGCCCTAGTTGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTACCCTCATTACTGATCCGACGTATTGATCA
GTTTGTGGCCGCGCATCCTGAATATGGAAGCCGTTCGGGCTTCCTTTCTCGCGTCGCTGCTGACAAGGTTATTAATCAAC
GATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References