Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3450563..3451220 Replicon chromosome
Accession NZ_CP011572
Organism Enterobacter hormaechei strain CAV1311

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag ABY62_RS17265 Protein ID WP_017382887.1
Coordinates 3450810..3451220 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ABY62_RS17260 Protein ID WP_003863437.1
Coordinates 3450563..3450829 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABY62_RS17240 3445969..3447402 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
ABY62_RS17245 3447519..3448250 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
ABY62_RS17250 3448517..3449176 + 660 WP_003863433.1 hemolysin III family protein -
ABY62_RS17255 3449288..3450268 - 981 WP_032619082.1 tRNA-modifying protein YgfZ -
ABY62_RS17260 3450563..3450829 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ABY62_RS17265 3450810..3451220 + 411 WP_017382887.1 protein YgfX Toxin
ABY62_RS17270 3451222..3451743 - 522 WP_015571793.1 flavodoxin FldB -
ABY62_RS17275 3451845..3452741 + 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
ABY62_RS17280 3452770..3453483 + 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ABY62_RS17285 3453489..3455222 + 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T54553 WP_017382887.1 NZ_CP011572:3450810-3451220 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T54553 NZ_CP011572:3450810-3451220 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT54553 WP_003863437.1 NZ_CP011572:3450563-3450829 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT54553 NZ_CP011572:3450563-3450829 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References