Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2290695..2291414 | Replicon | chromosome |
| Accession | NZ_CP011572 | ||
| Organism | Enterobacter hormaechei strain CAV1311 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A144XIR2 |
| Locus tag | ABY62_RS11670 | Protein ID | WP_023305176.1 |
| Coordinates | 2291094..2291414 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | ABY62_RS11665 | Protein ID | WP_032620726.1 |
| Coordinates | 2290695..2291060 (+) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ABY62_RS11640 | 2286993..2287427 | + | 435 | WP_044488933.1 | hypothetical protein | - |
| ABY62_RS24030 | 2287540..2288379 | + | 840 | WP_050595703.1 | hypothetical protein | - |
| ABY62_RS24470 | 2288438..2288629 | + | 192 | WP_023305181.1 | hypothetical protein | - |
| ABY62_RS11650 | 2289072..2289893 | + | 822 | WP_032620720.1 | DUF945 domain-containing protein | - |
| ABY62_RS11655 | 2289963..2290433 | + | 471 | WP_032620722.1 | DNA repair protein RadC | - |
| ABY62_RS11660 | 2290442..2290663 | + | 222 | WP_032620724.1 | DUF987 domain-containing protein | - |
| ABY62_RS11665 | 2290695..2291060 | + | 366 | WP_032620726.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ABY62_RS11670 | 2291094..2291414 | + | 321 | WP_023305176.1 | TA system toxin CbtA family protein | Toxin |
| ABY62_RS11675 | 2291617..2292198 | + | 582 | WP_017383635.1 | hypothetical protein | - |
| ABY62_RS11680 | 2292200..2292391 | - | 192 | WP_032620729.1 | toxin-antitoxin system HicB family antitoxin | - |
| ABY62_RS11685 | 2292528..2292869 | + | 342 | WP_032620730.1 | SymE family type I addiction module toxin | - |
| ABY62_RS11690 | 2292928..2293956 | + | 1029 | WP_071842900.1 | virulence RhuM family protein | - |
| ABY62_RS11695 | 2294220..2294705 | + | 486 | WP_017383637.1 | type VI secretion system tube protein Hcp | - |
| ABY62_RS24475 | 2294715..2295080 | + | 366 | WP_023302859.1 | DUF2778 domain-containing protein | - |
| ABY62_RS11700 | 2295143..2295664 | + | 522 | WP_017383638.1 | hypothetical protein | - |
| ABY62_RS11705 | 2295697..2296140 | - | 444 | WP_017383639.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2265452..2300019 | 34567 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12190.77 Da Isoelectric Point: 5.9559
>T54550 WP_023305176.1 NZ_CP011572:2291094-2291414 [Enterobacter hormaechei]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS
Download Length: 321 bp
>T54550 NZ_CP011572:2291094-2291414 [Enterobacter hormaechei]
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
Antitoxin
Download Length: 122 a.a. Molecular weight: 13574.29 Da Isoelectric Point: 6.4673
>AT54550 WP_032620726.1 NZ_CP011572:2290695-2291060 [Enterobacter hormaechei]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR
Download Length: 366 bp
>AT54550 NZ_CP011572:2290695-2291060 [Enterobacter hormaechei]
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|