Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4185184..4185779 Replicon chromosome
Accession NZ_CP011568
Organism Pandoraea thiooxydans strain DSM 25325

Toxin (Protein)


Gene name chpB Uniprot ID A0A0G3EXI2
Locus tag ABW99_RS19395 Protein ID WP_047215334.1
Coordinates 4185184..4185534 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3EU91
Locus tag ABW99_RS19400 Protein ID WP_047216708.1
Coordinates 4185528..4185779 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABW99_RS19370 4180740..4182029 + 1290 WP_047215330.1 amidase -
ABW99_RS19375 4182085..4183389 + 1305 WP_047215331.1 M20 family metallo-hydrolase -
ABW99_RS19380 4183410..4184009 + 600 WP_083566831.1 XRE family transcriptional regulator -
ABW99_RS19385 4184037..4184324 - 288 WP_047215332.1 DUF1330 domain-containing protein -
ABW99_RS19390 4184420..4184962 - 543 WP_047215333.1 flavin reductase family protein -
ABW99_RS19395 4185184..4185534 - 351 WP_047215334.1 type II toxin-antitoxin system ChpB family toxin Toxin
ABW99_RS19400 4185528..4185779 - 252 WP_047216708.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABW99_RS19405 4185921..4186856 - 936 WP_047215335.1 DMT family transporter -
ABW99_RS19410 4186945..4187859 + 915 WP_047215336.1 LysR family transcriptional regulator -
ABW99_RS19415 4187893..4188240 - 348 WP_072628677.1 cupin domain-containing protein -
ABW99_RS19420 4188503..4189468 - 966 WP_052892736.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-116)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12315.24 Da        Isoelectric Point: 10.4367

>T54547 WP_047215334.1 NZ_CP011568:c4185534-4185184 [Pandoraea thiooxydans]
MVRRVKFDRGDIVRVSLNPTAGREQQGDFRPVLVLSTALFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRALDLEARGAKKIERAPAEVVENALGRLQAILD

Download         Length: 351 bp

>T54547 NZ_CP011568:c4185534-4185184 [Pandoraea thiooxydans]
ATGGTGAGACGCGTCAAGTTTGATCGTGGCGACATCGTGCGCGTGAGTTTGAATCCGACGGCAGGTCGCGAGCAGCAGGG
AGATTTTCGCCCCGTCCTGGTGTTATCGACGGCATTGTTCAATGCGCTAGGCGTCGCCCTCGTTGCGCCAATCACGCAGG
GCGGCGAGTTCGCCCGATTCGCCGGCTTCGCGGTACCGCTGTCGGGTTCCGGCACCGAAACTCAGGGCGTTGCCTTGGTG
AACATGGTTCGCGCACTGGATCTCGAAGCTCGCGGAGCGAAGAAGATCGAGCGCGCGCCAGCAGAAGTGGTGGAGAATGC
ACTTGGCCGGCTGCAAGCGATATTGGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9049.63 Da        Isoelectric Point: 9.1196

>AT54547 WP_047216708.1 NZ_CP011568:c4185779-4185528 [Pandoraea thiooxydans]
MELSIQKWGNSAAVRLPAALLDQLKVALGDKLAVDVRPEGLMLKPARRKYALSELIAQCDPKASMPSDLAVWHGSAPVGR
EIW

Download         Length: 252 bp

>AT54547 NZ_CP011568:c4185779-4185528 [Pandoraea thiooxydans]
ATGGAACTGTCGATTCAAAAATGGGGCAATAGCGCAGCGGTGCGGCTACCGGCCGCGCTCCTTGATCAACTTAAAGTCGC
GCTGGGCGACAAGCTCGCTGTGGATGTGCGCCCGGAGGGGCTCATGCTGAAGCCGGCTCGGCGCAAGTATGCGCTCAGCG
AACTCATCGCACAGTGCGACCCGAAAGCGTCGATGCCGAGCGATTTGGCGGTTTGGCATGGGAGTGCTCCGGTAGGTCGT
GAGATATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3EXI2

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3EU91

References