Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3568057..3569861 Replicon chromosome
Accession NZ_CP011568
Organism Pandoraea thiooxydans strain DSM 25325

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag ABW99_RS16375 Protein ID WP_083566791.1
Coordinates 3568920..3569861 (-) Length 314 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ABW99_RS16370 Protein ID WP_156884764.1
Coordinates 3568057..3568923 (-) Length 289 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABW99_RS16350 3563286..3564782 - 1497 WP_047214813.1 aldehyde dehydrogenase -
ABW99_RS16355 3564807..3565625 - 819 WP_047214814.1 aspartate dehydrogenase -
ABW99_RS16360 3565618..3567270 - 1653 WP_047214815.1 thiamine pyrophosphate-binding protein -
ABW99_RS16365 3567263..3568060 - 798 WP_047214816.1 SDR family oxidoreductase -
ABW99_RS16370 3568057..3568923 - 867 WP_156884764.1 IclR family transcriptional regulator Antitoxin
ABW99_RS16375 3568920..3569861 - 942 WP_083566791.1 alpha/beta fold hydrolase Toxin
ABW99_RS16380 3569876..3570424 - 549 WP_047214818.1 cupin domain-containing protein -
ABW99_RS16385 3570451..3571221 - 771 WP_047214819.1 SDR family oxidoreductase -
ABW99_RS16390 3571239..3572021 - 783 WP_047214820.1 ABC transporter permease -
ABW99_RS16395 3572073..3572945 - 873 WP_083566792.1 ABC transporter ATP-binding protein -
ABW99_RS16400 3573242..3574315 - 1074 WP_047214821.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(64-290)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 31716.07 Da        Isoelectric Point: 6.6036

>T54544 WP_083566791.1 NZ_CP011568:c3569861-3568920 [Pandoraea thiooxydans]
MHSTANDAPLSPPPSASSATPDLLASAPAALLERLAAFPARRVSTRVGVIGYREAGASTAGTPLVLLHGIGSGAPSWLAQ
LEALGAAHRVLAWDAPGYGESAPLAAREPVAADYADALAAWLDALAIERVLLVGHSLGAVMAGAFARVAPQRVSGLLLCS
PAAGYGAASAEQRAAKRDARLALLESLGPAGLAAQRSANLLAPHAEPGARAWVQWNMARIVPDGYRQATHLLAQADLAAD
LTDYAGPVEVVVGAADAITPPAACEPIAAAARVPLQRIEGAGHACYIETPSSLNALIEALSRRANASASASKS

Download         Length: 942 bp

>T54544 NZ_CP011568:c3569861-3568920 [Pandoraea thiooxydans]
ATGCATTCGACCGCCAACGACGCGCCTTTGTCGCCGCCCCCGAGCGCCTCGTCCGCCACGCCGGACCTGCTGGCGAGCGC
GCCGGCGGCCCTGCTCGAGCGGCTGGCCGCGTTCCCGGCGCGCCGCGTGAGCACGCGCGTCGGCGTGATCGGCTACCGCG
AAGCCGGCGCATCGACGGCGGGCACGCCGTTGGTGCTGCTGCACGGCATCGGGTCGGGCGCGCCGTCGTGGCTGGCCCAG
CTCGAAGCGCTCGGCGCCGCGCATCGCGTGCTGGCTTGGGACGCTCCCGGTTATGGCGAGTCGGCGCCGCTGGCCGCGCG
AGAACCGGTCGCGGCCGACTATGCCGATGCGCTGGCGGCGTGGCTCGATGCGCTGGCGATCGAACGTGTGCTGCTGGTTG
GACACTCGCTCGGCGCGGTGATGGCCGGTGCCTTCGCGCGCGTGGCGCCGCAGCGCGTAAGCGGTTTGCTGCTGTGTTCG
CCCGCGGCCGGCTACGGCGCCGCCTCGGCCGAGCAACGCGCGGCCAAGCGCGACGCGCGCCTGGCTCTGCTCGAATCGCT
CGGCCCGGCCGGCCTGGCGGCCCAGCGCAGCGCCAATCTGCTGGCGCCGCACGCCGAGCCCGGTGCACGCGCCTGGGTCC
AATGGAACATGGCGCGCATCGTCCCCGACGGTTACCGGCAAGCCACGCATCTGCTCGCGCAAGCCGATCTGGCTGCCGAT
CTGACGGACTACGCCGGACCGGTCGAGGTCGTCGTGGGCGCTGCCGATGCGATAACCCCGCCCGCCGCTTGCGAGCCGAT
CGCGGCGGCCGCGCGCGTGCCGCTGCAACGCATCGAGGGCGCGGGCCATGCCTGCTATATCGAAACACCGTCGTCGCTGA
ACGCATTGATCGAAGCGCTCAGCCGGCGGGCCAACGCAAGCGCCAGCGCTTCAAAGTCATGA

Antitoxin


Download         Length: 289 a.a.        Molecular weight: 31505.00 Da        Isoelectric Point: 7.5215

>AT54544 WP_156884764.1 NZ_CP011568:c3568923-3568057 [Pandoraea thiooxydans]
MNSPMDNQDKADAAESRYSVPGLERGLKILTEFTPREPVLGAPELSRRLGIPRTTVFRLLQTLESMGFLERAGGDKNFRL
GVAVLRLGFEYLSSLELTDHGIPVLEKLRDATGFTSHIVIRDGRDIVFVAKAQSVAPVFSSIKVNVGTRLPAHATVHGHV
LMGDLTLDELMRLYPEGRLEKFTAQTPATVHDLYERVREDAARGYAVSSSSFERGISVVSAPVRSDLGRIVAAVTVTIPR
AEIDQPLLDSDLVGQVRQAAADLSRRLNYRPAPAAQAPSPARESLEIK

Download         Length: 867 bp

>AT54544 NZ_CP011568:c3568923-3568057 [Pandoraea thiooxydans]
ATGAACAGCCCAATGGACAATCAAGACAAGGCAGACGCCGCCGAGTCCCGTTACTCGGTGCCGGGGCTCGAGCGCGGACT
GAAGATTCTCACCGAGTTCACCCCGCGCGAGCCGGTGCTGGGCGCGCCGGAGCTCTCGCGTCGTCTCGGCATTCCCCGCA
CGACCGTCTTCCGGCTGCTGCAGACGCTCGAGTCGATGGGCTTTCTCGAACGTGCCGGCGGCGACAAGAATTTCCGTCTG
GGCGTGGCGGTGCTGCGCCTGGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGACCACGGCATTCCGGTGCTGGAGAA
GCTGCGCGACGCGACCGGCTTCACCAGCCACATCGTGATCCGCGACGGACGCGACATCGTGTTTGTCGCCAAGGCGCAAA
GCGTGGCGCCGGTGTTCAGCTCGATCAAGGTCAATGTCGGCACGCGGCTGCCGGCGCACGCCACCGTGCACGGGCACGTG
CTGATGGGCGACCTGACGCTCGACGAACTCATGCGGCTGTATCCGGAGGGACGCCTGGAGAAATTCACCGCGCAAACCCC
GGCCACCGTGCACGACCTGTACGAGCGGGTGCGCGAGGATGCCGCACGCGGCTACGCGGTGAGTTCGTCGTCGTTCGAGC
GCGGCATCTCGGTGGTCAGCGCACCGGTGCGCAGCGATCTCGGGCGCATTGTCGCGGCCGTGACGGTCACCATCCCGCGC
GCCGAAATCGATCAACCGCTGCTCGACAGCGATTTGGTGGGGCAGGTCAGGCAAGCGGCCGCCGATCTGTCGCGTCGCTT
GAACTACCGGCCGGCGCCAGCGGCTCAGGCACCGTCGCCGGCACGTGAATCACTGGAAATCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References