Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2075545..2076064 Replicon chromosome
Accession NZ_CP011568
Organism Pandoraea thiooxydans strain DSM 25325

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3ELG6
Locus tag ABW99_RS09645 Protein ID WP_047213572.1
Coordinates 2075545..2075826 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0G3ESX2
Locus tag ABW99_RS09650 Protein ID WP_047213574.1
Coordinates 2075816..2076064 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABW99_RS09620 2070973..2071956 - 984 WP_052892615.1 Flp pilus assembly protein CpaB -
ABW99_RS09625 2071979..2072476 - 498 WP_047213569.1 prepilin peptidase -
ABW99_RS09630 2072576..2072755 - 180 WP_047216378.1 Flp family type IVb pilin -
ABW99_RS09635 2073394..2074620 + 1227 WP_052892616.1 MFS transporter -
ABW99_RS09640 2074647..2075396 - 750 WP_047213571.1 IclR family transcriptional regulator -
ABW99_RS09645 2075545..2075826 - 282 WP_047213572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABW99_RS09650 2075816..2076064 - 249 WP_047213574.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ABW99_RS09655 2076149..2077447 - 1299 WP_047213576.1 tricarballylate/proton symporter TcuC -
ABW99_RS09660 2077604..2078779 + 1176 WP_047213577.1 CoA transferase -
ABW99_RS09665 2078776..2079546 + 771 WP_047213578.1 enoyl-CoA hydratase/isomerase family protein -
ABW99_RS09670 2079563..2080396 + 834 WP_047213580.1 CoA synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10589.33 Da        Isoelectric Point: 10.6505

>T54542 WP_047213572.1 NZ_CP011568:c2075826-2075545 [Pandoraea thiooxydans]
MSFELGFLDEALKEWRKLDASTREHFKAKLGERLANPRVPSAKLSGHANRYKIKLRNAGYRLVYEVRDSELIVVVVAVGK
CERAAVYKAAARR

Download         Length: 282 bp

>T54542 NZ_CP011568:c2075826-2075545 [Pandoraea thiooxydans]
ATGAGCTTTGAGCTGGGCTTTCTCGACGAGGCACTGAAGGAATGGCGCAAACTCGATGCGTCGACCCGGGAACACTTCAA
GGCCAAGTTAGGCGAGCGGCTGGCCAACCCGCGCGTGCCCAGCGCGAAGTTAAGCGGACATGCGAATCGTTACAAGATCA
AATTGCGCAACGCAGGCTATCGCCTGGTCTACGAAGTACGTGACAGCGAGTTGATCGTTGTAGTAGTCGCCGTAGGCAAG
TGCGAGCGAGCCGCAGTGTATAAAGCCGCGGCCCGGCGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.29 Da        Isoelectric Point: 4.2550

>AT54542 WP_047213574.1 NZ_CP011568:c2076064-2075816 [Pandoraea thiooxydans]
MPHRILAETTASVSELKRNPMGTVAAGDGLPVAILNRNEPAFYCVPAQAYEALMEKIEDMELNVIADARADQPVIKVTLD
EL

Download         Length: 249 bp

>AT54542 NZ_CP011568:c2076064-2075816 [Pandoraea thiooxydans]
ATGCCACATCGTATTCTCGCCGAGACCACCGCCAGCGTCTCTGAGCTCAAGCGCAACCCCATGGGGACCGTAGCCGCTGG
CGACGGGCTGCCGGTTGCGATTCTCAATCGCAATGAACCGGCCTTCTACTGCGTGCCGGCGCAAGCTTATGAAGCGTTGA
TGGAAAAAATCGAAGACATGGAGTTGAATGTCATCGCCGATGCTCGCGCCGACCAACCAGTCATCAAAGTAACGCTCGAT
GAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3ELG6

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3ESX2

References