Detailed information of TA system TA054540

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 5018022..5018535
• Replicon: chromosome
• Accession: NZ_CP011567
• Organism: Pseudomonas sp. GR 6-02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PGR6_RS29690
• Protein ID: WP_082920901.1
• Coordinates: 5018251..5018535 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2W7J5D4
• Locus tag: PGR6_RS22035
• Protein ID: WP_019647939.1
• Coordinates: 5018022..5018261 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PGR6_RS22005	5013673..5014203	+	531	WP_064619797.1	DUF2867 domain-containing protein	-
PGR6_RS22010	5014412..5014819	+	408	WP_064619800.1	low affinity iron permease family protein	-
PGR6_RS22015	5014862..5015365	-	504	WP_064619803.1	DUF4142 domain-containing protein	-
PGR6_RS22020	5015712..5017061	-	1350	WP_064619806.1	sensor domain-containing diguanylate cyclase	-
PGR6_RS22025	5017165..5017404	-	240	Protein_4376	LysE family translocator	-
PGR6_RS22030	5017441..5017857	-	417	WP_064619809.1	fosfomycin resistance glutathione transferase	-
PGR6_RS22035	5018022..5018261	+	240	WP_019647939.1	CopG family ribbon-helix-helix protein	Antitoxin
PGR6_RS29690	5018251..5018535	+	285	WP_082920901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PGR6_RS22040	5018633..5019964	-	1332	WP_064619812.1	MFS transporter	-
PGR6_RS22045	5020055..5020981	-	927	WP_064619815.1	hydroxymethylglutaryl-CoA lyase	-
PGR6_RS22050	5020978..5022171	-	1194	WP_019647936.1	CoA transferase	-
PGR6_RS22055	5022298..5023206	-	909	WP_018926832.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10894.71 Da
• Isoelectric Point: 11.0304

>T54540 WP_082920901.1 NZ_CP011567:5018251-5018535 [Pseudomonas sp. GR 6-02]
MRVEWLRTALKNLDDEAAYIAMENPKAAADFVKAILTTVDHLARFPATGREGRLPGTREWVLPDRPYLIPYRVRQGRLQV
LRVFHTRRLPPTTL

Nucleotide

• Length: 285 bp

>T54540 NZ_CP011567:5018251-5018535 [Pseudomonas sp. GR 6-02]
ATGCGCGTTGAGTGGTTGCGTACCGCATTAAAGAATCTGGATGACGAAGCCGCCTACATAGCAATGGAAAATCCAAAAGC
CGCAGCAGACTTCGTCAAGGCCATTCTCACCACCGTCGATCACCTTGCTCGCTTCCCGGCTACAGGCCGCGAAGGCCGAC
TACCTGGCACTCGGGAATGGGTCTTGCCAGACCGGCCCTATCTGATTCCCTATCGAGTTCGCCAAGGGCGTTTACAGGTA
CTACGAGTCTTCCATACACGACGTCTTCCACCCACTACGTTGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8788.99 Da
• Isoelectric Point: 4.8096

>AT54540 WP_019647939.1 NZ_CP011567:5018022-5018261 [Pseudomonas sp. GR 6-02]
MSIMSLRLPDEIADTLAHLAKATGRSKSFLAVDALREYLAREAWQIEEIQKALKEADAGDFATPEEVKAIADKWTTNAR

Nucleotide

• Length: 240 bp

>AT54540 NZ_CP011567:5018022-5018261 [Pseudomonas sp. GR 6-02]
ATGTCCATCATGTCGCTGCGTTTGCCAGACGAAATCGCCGATACCCTAGCCCATCTTGCCAAAGCGACAGGCCGCAGTAA
GTCATTTCTGGCCGTGGATGCGCTGCGTGAATATCTGGCACGGGAAGCCTGGCAAATCGAAGAGATTCAGAAAGCTCTGA
AAGAAGCCGACGCGGGTGACTTCGCAACGCCAGAGGAAGTGAAAGCAATCGCCGACAAGTGGACAACCAATGCGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2W7J5D4