Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5006437..5007060 Replicon chromosome
Accession NZ_CP011567
Organism Pseudomonas sp. GR 6-02

Toxin (Protein)


Gene name hicA Uniprot ID J3GAV2
Locus tag PGR6_RS21955 Protein ID WP_007984690.1
Coordinates 5006437..5006616 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2W7JPN3
Locus tag PGR6_RS21960 Protein ID WP_064619786.1
Coordinates 5006653..5007060 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGR6_RS21935 5001546..5002232 - 687 WP_064619779.1 cytochrome c oxidase subunit 3 -
PGR6_RS21940 5002229..5004004 - 1776 WP_064619781.1 cytochrome c oxidase subunit I -
PGR6_RS21945 5004053..5005525 - 1473 WP_064619784.1 cytochrome c oxidase subunit II -
PGR6_RS21950 5005834..5006169 + 336 WP_018926814.1 hypothetical protein -
PGR6_RS21955 5006437..5006616 + 180 WP_007984690.1 type II toxin-antitoxin system HicA family toxin Toxin
PGR6_RS21960 5006653..5007060 + 408 WP_064619786.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PGR6_RS21965 5007112..5007882 - 771 WP_064619788.1 trans-aconitate 2-methyltransferase -
PGR6_RS21970 5007954..5008283 - 330 WP_018926816.1 YXWGXW repeat-containing protein -
PGR6_RS21975 5008726..5009229 + 504 WP_019580873.1 inclusion body family protein -
PGR6_RS21980 5009354..5009893 + 540 WP_064619791.1 hypothetical protein -
PGR6_RS21985 5009978..5010436 - 459 WP_018926819.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6704.97 Da        Isoelectric Point: 11.4113

>T54539 WP_007984690.1 NZ_CP011567:5006437-5006616 [Pseudomonas sp. GR 6-02]
VNSRFLISQIVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Download         Length: 180 bp

>T54539 NZ_CP011567:5006437-5006616 [Pseudomonas sp. GR 6-02]
GTGAATAGCCGGTTTTTGATAAGCCAAATCGTTGCGGACGGCTGGTATCTGGTACGAATCAGGGGGAGTCATCACCACTT
CAAGCATCCGACCAAGCCTGGACTGGTGACGGTTCCTCACCCGAAAAAGGACCTGCTCAAGAAAACGGCCATTAGTATTT
TGCAACAGGCGCTGCTCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14676.66 Da        Isoelectric Point: 4.3833

>AT54539 WP_064619786.1 NZ_CP011567:5006653-5007060 [Pseudomonas sp. GR 6-02]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPQYAGCTWAV
VDIDITKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQS

Download         Length: 408 bp

>AT54539 NZ_CP011567:5006653-5007060 [Pseudomonas sp. GR 6-02]
ATGCTTTACCCCATCGCGATTTCCATGGGTGATGACGAACACGCCTGGGGCGTAGAAGTTCCGGATATTCCGGGTTGCTT
CTCCGCCGGTGAAGATCTGGATGACGCCATGGCCATGGCTCGCGAAGCCATCGAAGGTCATTTCGAGATTCTGGCCGAAG
ACGGATCACCGATTCCGCCCGCCAACAAAGTGACCCTGCATGCGGCCAATCCACAGTACGCAGGGTGCACGTGGGCCGTG
GTGGATATCGATATCACCAAATACCTGGGCAAGGCGCAGAAACTCAACATCACCCTGCCCGGCTATCTGCTCAACCGCAT
CGATGAGTACGTATTGCACCATCCGGAAGAGAAAAGTCGCTCCGGATTTCTGGCCTCGGCGGCGCTCAAGGTCTTGCAGC
AAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J3GAV2

Antitoxin

Source ID Structure
AlphaFold DB A0A2W7JPN3

References