Detailed information of TA system TA054538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 4719857..4720896
• Replicon: chromosome
• Accession: NZ_CP011567
• Organism: Pseudomonas sp. GR 6-02

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: PGR6_RS20685
• Protein ID: WP_064619432.1
• Coordinates: 4720321..4720896 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: PGR6_RS20680
• Protein ID: WP_064619430.1
• Coordinates: 4719857..4720324 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PGR6_RS20660	4715552..4716376	+	825	WP_064619420.1	ion transporter	-
PGR6_RS20665	4716483..4717481	+	999	WP_064619423.1	sulfate ABC transporter substrate-binding protein	-
PGR6_RS20670	4717539..4718171	-	633	WP_064619425.1	hypothetical protein	-
PGR6_RS20675	4718407..4719612	+	1206	WP_064619428.1	MFS transporter	-
PGR6_RS20680	4719857..4720324	+	468	WP_064619430.1	helix-turn-helix domain-containing protein	Antitoxin
PGR6_RS20685	4720321..4720896	+	576	WP_064619432.1	PIN domain-containing protein	Toxin
PGR6_RS20690	4720953..4721351	-	399	WP_064619435.1	hypothetical protein	-
PGR6_RS20695	4721366..4722574	-	1209	WP_064619438.1	c-type cytochrome biogenesis protein CcmI	-
PGR6_RS20700	4722567..4723040	-	474	WP_064619441.1	cytochrome c-type biogenesis protein CcmH	-
PGR6_RS20705	4723037..4723573	-	537	WP_018925073.1	DsbE family thiol:disulfide interchange protein	-
PGR6_RS20710	4723570..4725573	-	2004	WP_064619444.1	heme lyase CcmF/NrfE family subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21765.90 Da
• Isoelectric Point: 5.6166

>T54538 WP_064619432.1 NZ_CP011567:4720321-4720896 [Pseudomonas sp. GR 6-02]
VRHSPFTAVYDACVLYPAPLRDFLMWLALSGRFRARWSLEIHNEWKRNLLKNRPDLTTEQLDRTSDLMDQAIPDACVYGY
ERLIEGLTLPDVDDRHVLAAAIRCNASVIVTFNQKDFPDETLGPFGIEAQHPDEFVDNLFDLDPAAVVAAAQRQRKQLKT
PPMDVSTYLELLLRLGLTRSSKALTHYQAIL

Nucleotide

• Length: 576 bp

>T54538 NZ_CP011567:4720321-4720896 [Pseudomonas sp. GR 6-02]
GTGAGGCACTCCCCTTTTACCGCTGTATATGACGCATGTGTTTTGTACCCCGCGCCCTTGAGAGATTTTCTGATGTGGCT
CGCGCTCTCCGGGCGTTTCAGGGCGCGATGGTCACTGGAGATACATAACGAATGGAAGCGCAATCTACTGAAGAACCGCC
CGGACCTGACAACAGAGCAGTTGGATCGCACGTCCGACTTGATGGATCAGGCCATACCTGATGCTTGCGTCTACGGTTAC
GAAAGGCTGATCGAAGGGCTAACCCTACCTGACGTCGATGACCGACATGTTCTGGCTGCCGCTATACGCTGCAATGCCAG
TGTCATTGTGACCTTTAATCAGAAAGATTTTCCTGACGAAACACTGGGACCTTTTGGCATCGAGGCCCAGCATCCTGACG
AGTTCGTCGATAACCTCTTCGATCTGGACCCGGCAGCAGTTGTTGCGGCAGCACAACGACAACGCAAACAGCTAAAGACG
CCGCCGATGGATGTCAGCACTTATCTCGAACTGCTGTTACGCCTGGGCCTGACTCGGTCGAGCAAGGCGTTGACCCACTA
TCAGGCCATTCTTTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17243.68 Da
• Isoelectric Point: 5.5290

>AT54538 WP_064619430.1 NZ_CP011567:4719857-4720324 [Pseudomonas sp. GR 6-02]
MSPVIHPPLNLPMEREVQAAIEGQRALAACLATQFETQHIQIFDEQNEAHSVELPTSALRLLVDILAELAAGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESGELSYHKTGKHRRVRFTDLMDYKTQRDIASEQAMTLLAEQAQALRTGYE

Nucleotide

• Length: 468 bp

>AT54538 NZ_CP011567:4719857-4720324 [Pseudomonas sp. GR 6-02]
ATGTCACCAGTTATCCATCCCCCCCTTAACCTGCCCATGGAGCGTGAGGTCCAGGCCGCTATCGAAGGTCAGCGCGCCTT
GGCTGCCTGCCTCGCCACCCAATTCGAAACTCAGCATATCCAGATTTTCGATGAGCAGAATGAAGCACACAGCGTCGAAC
TTCCCACCTCAGCGCTTCGGTTGCTTGTCGACATCCTGGCAGAGCTCGCTGCAGGCAACGCCGTCAAAGTGGTCCCGGTA
CACGCTGAACTGACCACCCAGGAAGCGGCGGACTTGCTCAATGTCTCACGCCCGCACCTGATCAAACTGCTGGAGTCCGG
TGAGTTGTCCTACCACAAAACCGGCAAGCACCGACGTGTGCGCTTTACCGATTTGATGGACTATAAAACCCAGCGCGACA
TAGCCAGCGAGCAAGCAATGACGCTTCTCGCCGAGCAGGCACAAGCGTTAAGGACAGGATACGAGTGA