Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 5252459..5252964 Replicon chromosome
Accession NZ_CP011566
Organism Pseudomonas sp. DR 5-09

Toxin (Protein)


Gene name relE Uniprot ID Q3K782
Locus tag PDR5_RS23560 Protein ID WP_011335833.1
Coordinates 5252710..5252964 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0C2A0X2
Locus tag PDR5_RS23555 Protein ID WP_039765667.1
Coordinates 5252459..5252713 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PDR5_RS23530 5247792..5248157 + 366 WP_064599253.1 hypothetical protein -
PDR5_RS23535 5248182..5248928 - 747 WP_064599255.1 hypothetical protein -
PDR5_RS23540 5249048..5249401 + 354 WP_082934444.1 hypothetical protein -
PDR5_RS23545 5249522..5250268 + 747 WP_064599258.1 hypothetical protein -
PDR5_RS23550 5250340..5252259 + 1920 WP_064599260.1 alkaline phosphatase family protein -
PDR5_RS23555 5252459..5252713 + 255 WP_039765667.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PDR5_RS23560 5252710..5252964 + 255 WP_011335833.1 Txe/YoeB family addiction module toxin Toxin
PDR5_RS23565 5252973..5254145 - 1173 WP_064599262.1 aspartate aminotransferase family protein -
PDR5_RS23570 5254248..5255153 + 906 WP_064599264.1 LysR family transcriptional regulator -
PDR5_RS23575 5255207..5255611 + 405 WP_064599267.1 GNAT family N-acetyltransferase -
PDR5_RS23580 5255676..5256200 + 525 WP_064599269.1 hypothetical protein -
PDR5_RS23585 5256374..5257078 + 705 WP_039765656.1 hypothetical protein -
PDR5_RS23590 5257149..5257640 - 492 WP_064599271.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9950.59 Da        Isoelectric Point: 9.6300

>T54534 WP_011335833.1 NZ_CP011566:5252710-5252964 [Pseudomonas sp. DR 5-09]
MKIQFTPTGWEDYLWFQQNDKAGLKRINLLIKAIQRQPFEGLGKPEPLKHNMSGFWSRRITAEHRLVYAIVDGEICVITC
RFHY

Download         Length: 255 bp

>T54534 NZ_CP011566:5252710-5252964 [Pseudomonas sp. DR 5-09]
ATGAAAATCCAGTTCACGCCAACGGGCTGGGAAGACTACTTATGGTTTCAACAAAACGATAAGGCCGGTCTCAAACGAAT
CAATCTTTTGATCAAAGCGATCCAGCGCCAACCCTTTGAAGGCTTGGGTAAACCGGAGCCGCTCAAGCACAACATGAGCG
GCTTCTGGTCACGGCGGATAACTGCCGAGCATCGCTTGGTCTATGCGATCGTAGACGGCGAAATCTGCGTCATAACTTGC
AGATTTCACTACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.87 Da        Isoelectric Point: 5.1314

>AT54534 WP_039765667.1 NZ_CP011566:5252459-5252713 [Pseudomonas sp. DR 5-09]
MDTINYTTARAHLAETMDRVNEDCAPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSPANAERLIKSIGEMRAGKAKVRQ
LIEE

Download         Length: 255 bp

>AT54534 NZ_CP011566:5252459-5252713 [Pseudomonas sp. DR 5-09]
ATGGACACTATCAACTACACCACAGCTCGTGCGCACTTGGCCGAAACCATGGATCGCGTGAATGAAGACTGCGCCCCGCT
TCTGGTAACCCGCCAAAAAGGCGAGCCTGTAGTGATGATGTCTCTGGCCGAATACAACGCGCTGGAAGAAACGGCTTATC
TGCTGCGTTCTCCGGCCAATGCCGAGCGCTTGATCAAATCGATTGGCGAAATGCGCGCTGGAAAAGCCAAAGTCAGGCAA
CTGATTGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q3K782

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2A0X2

References