Detailed information of TA system TA054533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 4893029..4893705
• Replicon: chromosome
• Accession: NZ_CP011566
• Organism: Pseudomonas sp. DR 5-09

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: PDR5_RS21930
• Protein ID: WP_064598832.1
• Coordinates: 4893029..4893382 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: A0A0C1WFF8
• Locus tag: PDR5_RS21935
• Protein ID: WP_039773303.1
• Coordinates: 4893385..4893705 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PDR5_RS21905	4888630..4889616	+	987	WP_064598824.1	hypothetical protein	-
PDR5_RS21910	4889620..4890816	-	1197	WP_064598826.1	hypothetical protein	-
PDR5_RS21915	4890880..4891695	-	816	WP_064598828.1	sulfite exporter TauE/SafE family protein	-
PDR5_RS21920	4891808..4892575	+	768	WP_064598830.1	helix-turn-helix transcriptional regulator	-
PDR5_RS21925	4892669..4892986	+	318	WP_039773300.1	XRE family transcriptional regulator	-
PDR5_RS21930	4893029..4893382	+	354	WP_064598832.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PDR5_RS21935	4893385..4893705	+	321	WP_039773303.1	helix-turn-helix domain-containing protein	Antitoxin
PDR5_RS21940	4893718..4894770	-	1053	WP_064598834.1	MBL fold metallo-hydrolase	-
PDR5_RS21945	4894986..4895594	+	609	WP_064598835.1	TetR/AcrR family transcriptional regulator	-
PDR5_RS21950	4895741..4896793	+	1053	WP_064600928.1	diguanylate cyclase	-
PDR5_RS21955	4896969..4898288	+	1320	WP_064600930.1	PAS domain-containing methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 12988.90 Da
• Isoelectric Point: 9.7422

>T54533 WP_064598832.1 NZ_CP011566:4893029-4893382 [Pseudomonas sp. DR 5-09]
MSTRKPLLWVSSSKKDLKQMPTDVQDVFGYALDLAQSGLRHPDAKPLKGFGGAGVLELIEDFDTNTYRAVYTVRFGNAIY
VLHCFQKKSTTGIKSAQCDVDLIRKRLQAAQDHAKGT

Nucleotide

• Length: 354 bp

>T54533 NZ_CP011566:4893029-4893382 [Pseudomonas sp. DR 5-09]
ATGAGTACAAGGAAGCCACTCCTGTGGGTTAGCAGTAGCAAGAAAGATCTCAAGCAGATGCCCACTGATGTACAGGATGT
TTTTGGTTACGCACTGGATTTGGCCCAAAGCGGTCTCAGACATCCAGATGCAAAACCTCTGAAGGGGTTTGGAGGCGCGG
GTGTCCTCGAGTTGATTGAGGACTTTGATACGAATACCTACCGCGCCGTTTACACGGTCCGTTTTGGCAATGCAATTTAC
GTCCTGCATTGTTTTCAGAAAAAGTCGACCACCGGTATAAAATCCGCGCAGTGCGATGTCGATCTGATCCGAAAGAGACT
TCAAGCCGCTCAGGACCACGCGAAAGGAACTTAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11690.60 Da
• Isoelectric Point: 8.0411

>AT54533 WP_039773303.1 NZ_CP011566:4893385-4893705 [Pseudomonas sp. DR 5-09]
MIEIEEGSGNVYQDLGLPDASEMQVKSQLAAKIGEIIKARHLTQSQASEILGLSQPKLSEMLRGKFRGISEAKMMECLSH
LGRDVQIVVKPAPRSRKEGRIEVVFA

Nucleotide

• Length: 321 bp

>AT54533 NZ_CP011566:4893385-4893705 [Pseudomonas sp. DR 5-09]
ATGATTGAAATCGAAGAAGGCAGCGGCAACGTCTATCAAGACCTCGGCTTGCCCGACGCCAGTGAAATGCAGGTCAAGTC
TCAACTCGCCGCAAAGATCGGTGAAATCATCAAAGCGCGTCATCTCACTCAATCTCAAGCTTCTGAAATCTTGGGGTTAT
CACAACCCAAGCTATCCGAAATGCTGAGAGGAAAATTCCGCGGCATCAGTGAGGCCAAGATGATGGAATGCCTTTCCCAC
CTCGGCCGAGATGTGCAGATTGTGGTCAAACCGGCCCCCCGCTCTCGCAAAGAGGGCCGAATTGAAGTGGTGTTCGCATA
A

Structures

Antitoxin

• AlphaFold DB: A0A0C1WFF8