Detailed information of TA system TA054531

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1501678..1502302
• Replicon: chromosome
• Accession: NZ_CP011566
• Organism: Pseudomonas sp. DR 5-09

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PDR5_RS06765
• Protein ID: WP_064594067.1
• Coordinates: 1502120..1502302 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PDR5_RS06760
• Protein ID: WP_064594065.1
• Coordinates: 1501678..1502085 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PDR5_RS29135	1497771..1497926	+	156	WP_074691067.1	stress protein	-
PDR5_RS06735	1498002..1498505	+	504	WP_064594055.1	DUF4142 domain-containing protein	-
PDR5_RS06740	1498556..1498966	-	411	WP_064594057.1	low affinity iron permease family protein	-
PDR5_RS06745	1499181..1499951	+	771	WP_064594059.1	trans-aconitate 2-methyltransferase	-
PDR5_RS06750	1499991..1500719	-	729	WP_064594061.1	class I SAM-dependent methyltransferase	-
PDR5_RS06755	1501248..1501616	+	369	WP_064594063.1	hypothetical protein	-
PDR5_RS06760	1501678..1502085	-	408	WP_064594065.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PDR5_RS06765	1502120..1502302	-	183	WP_064594067.1	type II toxin-antitoxin system HicA family toxin	Toxin
PDR5_RS06775	1502988..1503872	-	885	WP_011332879.1	alpha/beta hydrolase	-
PDR5_RS06780	1504189..1504881	-	693	WP_064600709.1	pseudouridine synthase	-
PDR5_RS06785	1504915..1505145	-	231	WP_064594069.1	cysteine-rich CWC family protein	-
PDR5_RS06790	1505138..1506625	-	1488	WP_064594074.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6798.05 Da
• Isoelectric Point: 11.4113

>T54531 WP_064594067.1 NZ_CP011566:c1502302-1502120 [Pseudomonas sp. DR 5-09]
VNSRFLIGQLVADGWYLVRVRGSHHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Nucleotide

• Length: 183 bp

>T54531 NZ_CP011566:c1502302-1502120 [Pseudomonas sp. DR 5-09]
GTGAATAGCCGCTTTCTAATTGGCCAGCTCGTCGCAGACGGTTGGTATCTGGTGCGGGTCAGGGGCAGTCATCATCATCA
CTTCAAGCATCCGACCAAACCTGGTCTGGTCACAGTGCCTCACCCGAAGAAGGATCTGCTCAAGAAAACGGCCATCAGTA
TTTTGCAGCAGGCGCTGCTCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14572.58 Da
• Isoelectric Point: 4.5801

>AT54531 WP_064594065.1 NZ_CP011566:c1502085-1501678 [Pseudomonas sp. DR 5-09]
MLYPIAISVGDEGHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQS

Nucleotide

• Length: 408 bp

>AT54531 NZ_CP011566:c1502085-1501678 [Pseudomonas sp. DR 5-09]
ATGCTTTACCCGATCGCGATTTCAGTGGGTGATGAAGGACATGCCTGGGGAGTGGAGGTGCCGGATATTCCGGGCTGCTT
CTCCGCTGGAGATGATCTGGACGATGCAATGGCCATGGCTCGCGAAGCCATCGAAGGCCATTTCGAGATTCTGGCAGAGG
ACGGTTCCCCGATCCCGCCAGCCAACAAGGTCACGCTGCATGCCGCCAATCCAAAATACGCTGGCTGCACGTGGGCGTTG
GTGGACATCGATGTAACCAAATACCTGGGCAAAGCTCAAAAACTCAACATCACATTGCCGGGGTACCTGCTGAACCGTAT
TGATGAATACGTGTTGCATCACCCGGAAGAGAAAAGCCGCTCCGGATTCCTGGCCTCGGCGGCGCTCAAGGTGTTGCAGC
AAAGTTGA