Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 481992..482581 Replicon chromosome
Accession NZ_CP011566
Organism Pseudomonas sp. DR 5-09

Toxin (Protein)


Gene name PumA Uniprot ID A0A0C1WIU8
Locus tag PDR5_RS02125 Protein ID WP_039766452.1
Coordinates 481992..482297 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q3KJ92
Locus tag PDR5_RS02130 Protein ID WP_011332089.1
Coordinates 482294..482581 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PDR5_RS02105 478007..479074 + 1068 WP_007968321.1 uroporphyrinogen decarboxylase -
PDR5_RS02110 479146..480420 - 1275 WP_064592913.1 MFS transporter -
PDR5_RS02115 480539..481435 + 897 WP_039766450.1 LysR family transcriptional regulator -
PDR5_RS02120 481436..481873 - 438 WP_064592915.1 hypothetical protein -
PDR5_RS02125 481992..482297 + 306 WP_039766452.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PDR5_RS02130 482294..482581 + 288 WP_011332089.1 putative addiction module antidote protein Antitoxin
PDR5_RS02135 482630..483070 - 441 WP_064592917.1 hypothetical protein -
PDR5_RS02140 483091..484326 - 1236 WP_064592919.1 beta-ketoacyl-ACP synthase -
PDR5_RS02145 484326..485054 - 729 WP_039766460.1 3-oxoacyl-ACP reductase FabG -
PDR5_RS02150 485047..485526 - 480 WP_064592921.1 hotdog family protein -
PDR5_RS02155 485523..486719 - 1197 WP_064592923.1 beta-ketoacyl-[acyl-carrier-protein] synthase family protein -
PDR5_RS02160 486716..487198 - 483 WP_064592925.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11483.10 Da        Isoelectric Point: 9.6535

>T54530 WP_039766452.1 NZ_CP011566:481992-482297 [Pseudomonas sp. DR 5-09]
MTEILRSSTFSSWLVKLADSRARMRIQVRIDRMAEGNFGDVKAIGEGISEARIDYGPGYRVYFMQQGRQLVILLCGGDKS
SQSRDIKQARLIAESWQEQNP

Download         Length: 306 bp

>T54530 NZ_CP011566:481992-482297 [Pseudomonas sp. DR 5-09]
ATGACTGAGATACTTCGAAGCTCCACATTCTCGAGCTGGCTTGTGAAGCTGGCTGATAGTCGCGCCAGGATGCGTATTCA
GGTGCGAATTGATCGTATGGCTGAAGGAAACTTCGGTGATGTCAAAGCCATTGGCGAAGGGATCAGCGAAGCCCGAATTG
ACTATGGCCCGGGATATCGGGTCTATTTCATGCAGCAAGGTCGTCAGCTGGTCATCCTCCTTTGTGGTGGAGACAAGAGC
AGTCAATCTCGAGACATCAAGCAAGCCAGGCTCATCGCGGAATCCTGGCAGGAGCAAAACCCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10446.86 Da        Isoelectric Point: 4.6412

>AT54530 WP_011332089.1 NZ_CP011566:482294-482581 [Pseudomonas sp. DR 5-09]
MTEQFTRWDSAEYLKTEEDMANYLDACMEEAGDDPAFIAKALGTIARARGMTQVARDAGLSRESLYRALSGEVNPEFGTI
LKVMKALGLKLHAST

Download         Length: 288 bp

>AT54530 NZ_CP011566:482294-482581 [Pseudomonas sp. DR 5-09]
ATGACCGAACAATTCACTCGTTGGGACTCAGCCGAGTACCTCAAGACAGAAGAGGACATGGCCAACTATCTGGATGCCTG
CATGGAAGAGGCGGGGGATGACCCGGCTTTTATTGCCAAGGCACTTGGCACAATTGCTCGGGCGCGTGGCATGACCCAGG
TCGCGCGGGATGCGGGGCTATCAAGGGAAAGTCTTTATCGCGCACTGTCAGGCGAGGTAAATCCCGAGTTTGGAACGATC
CTCAAAGTCATGAAAGCGCTGGGGCTGAAGTTGCATGCCAGCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1WIU8

Antitoxin

Source ID Structure
AlphaFold DB A0A345RJ97

References