Detailed information of TA system TA054529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 340398..341037
• Replicon: chromosome
• Accession: NZ_CP011566
• Organism: Pseudomonas sp. DR 5-09

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A3T0K2L6
• Locus tag: PDR5_RS01490
• Protein ID: WP_064384144.1
• Coordinates: 340398..340580 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PDR5_RS01495
• Protein ID: WP_064592786.1
• Coordinates: 340612..341037 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PDR5_RS01455	335530..336246	+	717	WP_011331997.1	AzlC family ABC transporter permease	-
PDR5_RS01460	336225..336542	+	318	WP_007952614.1	AzlD domain-containing protein	-
PDR5_RS01465	336459..337385	-	927	WP_064592778.1	LysR family transcriptional regulator	-
PDR5_RS01470	338014..338232	+	219	WP_007952610.1	4-oxalocrotonate tautomerase family protein	-
PDR5_RS01475	338229..338873	+	645	WP_064592780.1	DsbA family oxidoreductase	-
PDR5_RS01480	338907..339617	+	711	WP_064592782.1	SDR family oxidoreductase	-
PDR5_RS01485	339676..339942	-	267	WP_064592784.1	DUF3077 domain-containing protein	-
PDR5_RS01490	340398..340580	+	183	WP_064384144.1	type II toxin-antitoxin system HicA family toxin	Toxin
PDR5_RS01495	340612..341037	+	426	WP_064592786.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PDR5_RS01500	341330..343048	-	1719	WP_064592788.1	deoxycytidylate deaminase	-
PDR5_RS29600	343086..343235	-	150	WP_156669306.1	hypothetical protein	-
PDR5_RS29025	343318..343966	+	649	Protein_295	ATP-binding protein	-
PDR5_RS29030	344049..344444	+	396	WP_082934348.1	recombinase family protein	-
PDR5_RS29035	344531..344836	+	306	WP_082934349.1	recombinase family protein	-
PDR5_RS01520	345002..345238	+	237	WP_064592796.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	339676..350511	10835

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6810.86 Da
• Isoelectric Point: 10.8173

>T54529 WP_064384144.1 NZ_CP011566:340398-340580 [Pseudomonas sp. DR 5-09]
MKYSEFRRWLKAQGVEFQTGKGSHFKVSLNGRSTVFPDHGAKEMGEGLRKSIIKQLGLKD

Nucleotide

• Length: 183 bp

>T54529 NZ_CP011566:340398-340580 [Pseudomonas sp. DR 5-09]
ATGAAGTACAGCGAGTTTCGGCGATGGTTGAAAGCCCAAGGCGTTGAGTTCCAAACCGGCAAGGGCAGCCATTTCAAGGT
TTCCTTGAATGGCCGATCAACTGTCTTTCCCGACCACGGAGCCAAGGAGATGGGCGAAGGGTTGAGAAAATCGATAATCA
AACAGCTGGGCCTCAAGGATTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15515.64 Da
• Isoelectric Point: 4.5140

>AT54529 WP_064592786.1 NZ_CP011566:340612-341037 [Pseudomonas sp. DR 5-09]
MFEYALEVHEEPSSVWLSCAEIPEMHAAGDTLKEALDGAIDAMETALSIYVDDRRLIPTGDAGEQESDAVLRLPALTAAK
VGLWNTLLESGVSKAELARRLGVQRPQVDRLVDFLHHSKIENVERALQQLGRRILLSVEAA

Nucleotide

• Length: 426 bp

>AT54529 NZ_CP011566:340612-341037 [Pseudomonas sp. DR 5-09]
ATGTTCGAATATGCGTTGGAAGTCCACGAGGAGCCGAGCAGTGTCTGGTTGTCCTGCGCAGAAATTCCAGAGATGCACGC
CGCTGGCGACACCCTCAAGGAAGCGCTCGACGGCGCCATAGATGCAATGGAGACGGCCTTGTCGATTTACGTTGATGATC
GTCGGTTGATTCCGACAGGTGATGCGGGAGAGCAGGAAAGTGACGCTGTTTTGCGTCTGCCTGCACTGACTGCCGCAAAG
GTCGGGTTGTGGAATACCCTTCTCGAGTCTGGGGTGAGCAAGGCTGAACTGGCACGGCGCTTGGGTGTGCAACGACCCCA
GGTAGATCGGTTAGTCGATTTCCTGCATCACTCCAAGATAGAGAATGTCGAGCGTGCATTGCAGCAGCTTGGACGGCGGA
TTTTGCTTTCGGTTGAGGCTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A3T0K2L6