Detailed information of TA system TA054526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1994589..1995070
• Replicon: chromosome
• Accession: NZ_CP011541
• Organism: Corynebacterium epidermidicanis strain DSM 45586

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: CEPID_RS13165
• Protein ID: WP_144413504.1
• Coordinates: 1994589..1994786 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CEPID_RS09165
• Protein ID: WP_047240721.1
• Coordinates: 1994783..1995070 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEPID_RS09150	1991220..1993688	+	2469	WP_047240719.1	CHAT domain-containing protein	-
CEPID_RS13160	1994102..1994329	+	228	WP_144413503.1	hypothetical protein	-
CEPID_RS13165	1994589..1994786	+	198	WP_144413504.1	hypothetical protein	Toxin
CEPID_RS09165	1994783..1995070	+	288	WP_047240721.1	putative addiction module antidote protein	Antitoxin
CEPID_RS12940	1995123..1995509	-	387	Protein_1796	elongation factor 4	-
CEPID_RS12540	1995604..1996983	+	1380	WP_052843482.1	hypothetical protein	-
CEPID_RS09180	1996994..1997587	-	594	Protein_1798	Type 1 glutamine amidotransferase-like domain-containing protein	-
CEPID_RS09185	1998100..1998534	+	435	WP_061363644.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-61)

Antitoxin

• Uncharacterized protein HI1420 (13-91)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7188.26 Da
• Isoelectric Point: 8.5558

>T54526 WP_144413504.1 NZ_CP011541:1994589-1994786 [Corynebacterium epidermidicanis]
MLGDIKSVGNSVQELRFHFGPGYRIYFTEFGGITVFLLAGGDKSTQSKDIATAQKMATELKEKMQ

Nucleotide

• Length: 198 bp

>T54526 NZ_CP011541:1994589-1994786 [Corynebacterium epidermidicanis]
ATGCTGGGAGACATCAAGTCTGTTGGAAACTCAGTCCAAGAGCTCAGGTTTCATTTTGGGCCCGGATACCGCATCTATTT
CACGGAGTTTGGCGGAATAACAGTTTTCCTCTTAGCAGGAGGGGACAAATCGACCCAATCGAAAGACATTGCTACGGCCC
AGAAAATGGCCACTGAACTGAAGGAGAAAATGCAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10297.72 Da
• Isoelectric Point: 5.8314

>AT54526 WP_047240721.1 NZ_CP011541:1994783-1995070 [Corynebacterium epidermidicanis]
MSATYSHFDASKYLDSESAIEEYLAIALEEGDNKTIQLVLRDIAKARGMSELAKATGLNRESLYKSLSKEGNPSFATILK
VVNALGLQITLKSAS

Nucleotide

• Length: 288 bp

>AT54526 NZ_CP011541:1994783-1995070 [Corynebacterium epidermidicanis]
ATGAGCGCGACATACTCACATTTTGACGCGAGCAAGTACCTCGATTCGGAATCTGCAATCGAAGAGTACTTGGCAATTGC
CCTCGAAGAAGGCGACAACAAGACCATTCAGTTGGTACTGCGAGATATTGCCAAAGCACGCGGGATGAGCGAGCTCGCAA
AAGCGACAGGACTAAACCGGGAATCCCTGTATAAATCACTATCCAAGGAAGGAAATCCATCGTTCGCCACGATCCTCAAG
GTCGTAAATGCTCTTGGCTTGCAAATAACGTTGAAGTCGGCGAGCTAA