Detailed information of TA system TA054525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-YefM
• Location: 620443..620957
• Replicon: chromosome
• Accession: NZ_CP011541
• Organism: Corynebacterium epidermidicanis strain DSM 45586

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CEPID_RS12830
• Protein ID: WP_083984351.1
• Coordinates: 620703..620957 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0G3GSG8
• Locus tag: CEPID_RS02930
• Protein ID: WP_047239691.1
• Coordinates: 620443..620697 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEPID_RS02890	615540..616040	+	501	WP_047239685.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CEPID_RS02895	616041..616487	+	447	WP_047239686.1	YdcF family protein	-
CEPID_RS02900	616484..616747	-	264	WP_047239687.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CEPID_RS02905	616755..617009	-	255	WP_047239688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CEPID_RS02910	617050..617682	-	633	WP_047239689.1	response regulator transcription factor	-
CEPID_RS12405	617679..618812	-	1134	WP_052843332.1	histidine kinase	-
CEPID_RS02920	618823..619650	-	828	WP_047239690.1	hypothetical protein	-
CEPID_RS02925	619653..620312	-	660	WP_047241301.1	ABC transporter ATP-binding protein	-
CEPID_RS02930	620443..620697	+	255	WP_047239691.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CEPID_RS12830	620703..620957	+	255	WP_083984351.1	Txe/YoeB family addiction module toxin	Toxin
CEPID_RS02940	620926..621387	-	462	WP_047239693.1	hypothetical protein	-
CEPID_RS02945	621558..622691	-	1134	WP_047239694.1	hydrogenase formation protein HypD	-
CEPID_RS02950	622688..622951	-	264	WP_047239695.1	HypC/HybG/HupF family hydrogenase formation chaperone	-
CEPID_RS02955	623024..624127	+	1104	WP_083984352.1	hydrogenase expression/formation protein HypE	-
CEPID_RS13470	624151..624531	-	381	WP_047239696.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10227.62 Da
• Isoelectric Point: 7.3570

>T54525 WP_083984351.1 NZ_CP011541:620703-620957 [Corynebacterium epidermidicanis]
MLLTWDENVWEDYLWWQAHDRKVLKRINTLIKDIARNGNEGIGKPEPLKHEFAGFWSRRITEEHRLVYRASENEITVLAC
RYHY

Nucleotide

• Length: 255 bp

>T54525 NZ_CP011541:620703-620957 [Corynebacterium epidermidicanis]
ATGCTCCTCACTTGGGATGAGAATGTCTGGGAAGATTATCTGTGGTGGCAAGCGCACGACCGGAAAGTCTTGAAGCGGAT
CAATACTCTGATCAAGGACATTGCCAGGAATGGCAACGAGGGAATCGGTAAGCCCGAGCCACTGAAACATGAATTTGCCG
GATTCTGGTCTCGACGAATCACTGAAGAGCATCGCCTCGTCTACCGAGCGAGCGAAAACGAAATCACTGTGCTGGCTTGT
CGTTACCATTACTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9578.70 Da
• Isoelectric Point: 4.5084

>AT54525 WP_047239691.1 NZ_CP011541:620443-620697 [Corynebacterium epidermidicanis]
MKTISYTESRANYARVLDEVVNDREPVTITRAGHESVVMMSLDDYSSLQETAYLMRSPANARRLFDALERVKAGDVTEHE
LIED

Nucleotide

• Length: 255 bp

>AT54525 NZ_CP011541:620443-620697 [Corynebacterium epidermidicanis]
ATGAAGACGATCAGTTACACCGAGTCGCGTGCGAATTATGCGCGGGTACTGGATGAAGTTGTCAATGATCGCGAACCTGT
CACCATTACGCGGGCGGGCCACGAATCTGTCGTGATGATGTCCCTAGATGATTACTCGTCATTGCAGGAAACCGCTTACC
TTATGCGTTCTCCGGCAAATGCCCGACGGCTTTTCGACGCGCTGGAGCGTGTGAAAGCTGGGGATGTAACAGAGCACGAG
CTCATTGAGGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0G3GSG8