Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 5303973..5304753 Replicon chromosome
Accession NZ_CP011539
Organism Klebsiella aerogenes strain G7

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag EAG7_RS25015 Protein ID WP_015370123.1
Coordinates 5303973..5304302 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EAG7_RS25020 Protein ID WP_127175768.1
Coordinates 5304355..5304753 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAG7_RS29615 5299341..5299493 - 153 WP_157844032.1 hypothetical protein -
EAG7_RS28040 5299784..5300011 + 228 WP_071647620.1 DUF1272 domain-containing protein -
EAG7_RS24995 5300339..5301157 + 819 WP_032706441.1 AraC family transcriptional regulator -
EAG7_RS25000 5301233..5301595 + 363 WP_015370120.1 cupin domain-containing protein -
EAG7_RS25005 5301795..5302331 + 537 WP_015370121.1 dihydrofolate reductase family protein -
EAG7_RS25010 5302507..5303307 + 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
EAG7_RS29360 5303466..5303567 - 102 Protein_4974 preprotein translocase -
EAG7_RS25015 5303973..5304302 - 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
EAG7_RS25020 5304355..5304753 - 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EAG7_RS25025 5304722..5304943 - 222 WP_015370125.1 DUF987 domain-containing protein -
EAG7_RS25030 5304964..5305443 - 480 WP_015370126.1 DNA repair protein RadC -
EAG7_RS25035 5305455..5305934 - 480 WP_032710462.1 antirestriction protein -
EAG7_RS28045 5305951..5306205 - 255 WP_071647618.1 hypothetical protein -
EAG7_RS25040 5306205..5307023 - 819 WP_015370128.1 DUF945 domain-containing protein -
EAG7_RS25045 5307121..5307354 - 234 WP_015370129.1 DUF905 domain-containing protein -
EAG7_RS25050 5307448..5308284 - 837 WP_015370130.1 hypothetical protein -
EAG7_RS25055 5308342..5308587 - 246 WP_032710460.1 hypothetical protein -
EAG7_RS25060 5308587..5308814 - 228 WP_015370132.1 hypothetical protein -
EAG7_RS25065 5308887..5309294 - 408 WP_032710459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5301233..5330908 29675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T54523 WP_015370123.1 NZ_CP011539:c5304302-5303973 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T54523 NZ_CP011539:c5304302-5303973 [Klebsiella aerogenes]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT54523 WP_127175768.1 NZ_CP011539:c5304753-5304355 [Klebsiella aerogenes]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT54523 NZ_CP011539:c5304753-5304355 [Klebsiella aerogenes]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATTGCCGAACCCTGGTGGGGACTCAAAACCACCGTCACGCCGTACTTTGGCGCACGACTGGTGCAGGAAGGCA
ACCGGCTGCATTACCTGGCTGATCGTGCCAGTATCACCGGGACATTCAGCGACGCGGATTTACGCCATCTCGACCAGGCG
TTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACCTCCCGCCATCAGCACCGCATCACGCT
ATATCACAATGGACTGACTTGCGAAGCCGATACACTCGGCTCTTGTGGTTACGTCTACATCGCTATTTATCCCGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References