Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4966452..4967109 Replicon chromosome
Accession NZ_CP011539
Organism Klebsiella aerogenes strain G7

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag EAG7_RS23405 Protein ID WP_015369792.1
Coordinates 4966699..4967109 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag EAG7_RS23400 Protein ID WP_015369791.1
Coordinates 4966452..4966718 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAG7_RS23375 4961679..4963112 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
EAG7_RS23380 4963232..4963960 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
EAG7_RS23385 4964011..4964322 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
EAG7_RS23390 4964487..4965146 + 660 WP_008806429.1 hemolysin III family protein -
EAG7_RS23395 4965245..4966228 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
EAG7_RS23400 4966452..4966718 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
EAG7_RS23405 4966699..4967109 + 411 WP_015369792.1 protein YgfX Toxin
EAG7_RS23410 4967117..4967638 - 522 WP_015369793.1 flavodoxin FldB -
EAG7_RS23415 4967739..4968635 + 897 WP_015369794.1 site-specific tyrosine recombinase XerD -
EAG7_RS23420 4968658..4969371 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EAG7_RS23425 4969377..4971110 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T54522 WP_015369792.1 NZ_CP011539:4966699-4967109 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T54522 NZ_CP011539:4966699-4967109 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTAATCGACTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAGCCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT54522 WP_015369791.1 NZ_CP011539:4966452-4966718 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT54522 NZ_CP011539:4966452-4966718 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGATAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References